Evidence map›Paper›PMID 31115653›Full record

ArticleMedical microbiology and immunology2019

Caspase-8 restricts natural killer cell accumulation during MCMV Infection.

Yanjun Feng, Lisa P Daley-Bauer, Linda Roback, Marc Potempa, Lewis L Lanier, Edward S Mocarski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical microbiology and immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Programmed Necrosis in Host Defense.Current topics in microbiology and immunology · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yanjun FengDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, 1462 Clifton Rd. N.E, Atlanta, GA, 30322, USA.
Lisa P Daley-BauerDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, 1462 Clifton Rd. N.E, Atlanta, GA, 30322, USA.
Linda RobackDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, 1462 Clifton Rd. N.E, Atlanta, GA, 30322, USA.
Marc PotempaDepartment of Microbiology and Immunology and Parker Institute for Cancer Immunotherapy, University of California, San Francisco, CA, 94143, USA.
Lewis L LanierDepartment of Microbiology and Immunology and Parker Institute for Cancer Immunotherapy, University of California, San Francisco, CA, 94143, USA.
Edward S MocarskiDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, 1462 Clifton Rd. N.E, Atlanta, GA, 30322, USA. mocarski@emory.edu.
Emory University · USUniversity of California, San Francisco · US

Funding

Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
NK MemoryR01AI068129 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2020
$6.0M
CYTOMEGALOVIRUS DNA REPLICATION AND RECOMBINATIONR01AI020211 · NIAID · STANFORD UNIVERSITY · PI EDWARD S MOCARSKI, EDWARD S. · 1985 to 2021
$5.9M
Innate activation and death signals in health and diseaseR01AI118853 · NIAID · EMORY UNIVERSITY · PI EDWARD S MOCARSKI, EDWARD S. · 2015 to 2018
$1.7M
NIAID NIH HHS R01 AI020211NIAID NIH HHS R01 AI068129NIAID NIH HHS R01 AI118853NIAID NIH HHS T32 AI060537NIH HHS AI020211
6 · The paper itself

Abstract

Natural killer (NK) cells provide important host defense against herpesvirus infections and influence subsequent T cell control of replication and maintenance of latency. NK cells exhibit phases of expansion, contraction and memory formation in response to the natural mouse pathogen murine cytomegalovirus (MCMV). Innate and adaptive immune responses are tightly regulated in mammals to avoid excess tissue damage while preventing acute and chronic viral disease and assuring resistance to reinfection. Caspase (CASP)8 is an autoactivating aspartate-specific cysteine protease that initiates extrinsic apoptosis and prevents receptor interacting protein (RIP) kinase (RIPK)1-RIPK3-driven necroptosis. CASP8 also promotes death-independent signal transduction. All of these activities make contributions to inflammation. Here, we demonstrate that CASP8 restricts NK cell expansion during MCMV infection but does not influence NK memory. Casp8

Indexed as

AnimalsCaspase 8Cytomegalovirus InfectionsDisease Models, AnimalKiller Cells, NaturalMiceMice, Inbred C57BLMuromegalovirusCasp8 protein, mouseCaspase 8ApoptosisCell deathHerpesvirusNecroptosisProliferationRipoptosome

Identifiers

PMID31115653
PMCPMC6635065
OpenAlexW2946232509

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.