Evidence map›Paper›PMID 31129175›Full record

ReviewAlcohol (Fayetteville, N.Y.)2020

Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: From Genetics to nutrition: Summary of the ISBRA 2018 symposium.

Irina A Kirpich, Dennis R Warner, Wenke Feng, Swati Joshi-Barve, Craig J McClain, Devanshi Seth, Wei Zhong, Zhanxiang Zhou, Natalia A Osna, Kusum K Kharbanda

Open access · greenAbstract readReview
In one paragraph

Review in Alcohol (Fayetteville, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Second hits exacerbate alcohol-related organ damage: an update.Alcohol and alcoholism (Oxford, Oxfordshire) · 2021
    Review
  7. Article
  8. Review
  9. Microbiome dysbiosis and alcoholic liver diseaseLiver research (Beijing, China) · 2019
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Irina A KirpichDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, USA; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, KY, USA; Robley Rex Veterans Medical Center, Louisville, KY, USA; Hepatobiology & Toxicology Program, University of Louisville, Louisville, KY, USA.
Dennis R WarnerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, USA.
Wenke FengDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, USA; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, KY, USA; Hepatobiology & Toxicology Program, University of Louisville, Louisville, KY, USA.
Swati Joshi-BarveDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, USA; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, KY, USA; Hepatobiology & Toxicology Program, University of Louisville, Louisville, KY, USA.
Craig J McClainDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, USA; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA; University of Louisville Alcohol Center, University of Louisville School of Medicine, Louisville, KY, USA; Robley Rex Veterans Medical Center, Louisville, KY, USA; Hepatobiology & Toxicology Program, University of Louisville, Louisville, KY, USA.
Devanshi SethDrug Health Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia, And Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, Sydney, NSW, Australia.
Wei ZhongCenter for Translational Biomedical Research, Department of Nutrition, University of North Carolina at Greensboro, Kannapolis, NC, 28081, USA.
Zhanxiang ZhouCenter for Translational Biomedical Research, Department of Nutrition, University of North Carolina at Greensboro, Kannapolis, NC, 28081, USA.
Natalia A OsnaResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, USA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Kusum K KharbandaResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, USA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA; Department of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: kkharbanda@unmc.edu.
University of Louisville · USUniversity of Nebraska Medical Center · USUniversity of North Carolina at Greensboro · USCentenary Institute · AULouisville VA Medical Center · US

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI CAVE, MATTHEW C · 2016 to 2025
$24.1M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · PI CRAIG J. MCCLAIN · 2016 to 2026
$17.9M
Aldehydes in Alcohol-Induced Organ InjuryR01AA020212 · NIAAA · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI ZHANXIANG ZHOU · 2010 to 2026
$6.4M
Novel Therapies for Alcoholic HepatitisU01AA021893 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI MCCLAIN, CRAIG J., MCCULLOUGH, ARTHUR JOSEPH · 2012 to 2017
$6.0M
Mechanisms of Probiotics in Alcoholic Liver DiseaseR01AA023190 · NIAAA · UNIVERSITY OF LOUISVILLE · PI FENG, WENKE · 2015 to 2024
$3.5M
The role of dietary unsaturated fat and inflammasome in alcoholic liver diseaseR01AA024102 · NIAAA · UNIVERSITY OF LOUISVILLE · PI KIRPICH, IRINA A. · 2016 to 2020
$1.7M
Oxidized Metabolites of Linoleic Acid in Alcohol-induced Liver InjuryU01AA022489 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL, MCCLAIN, CRAIG J. · 2014 to 2018
$1.7M
Mechanisms for alcohol induced gut barrier dysfunction in ALDR01AA023681 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2014 to 2018
$1.6M
Impaired phospholipid methylation results in decreased lipid droplet lipolysis: Role in hepatic steatosisR01AA026723 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KHARBANDA, KUSUM K. · 2018 to 2022
$1.6M
Novel therapies in alcoholic hepatitis University of LouisvilleU01AA021901 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2012 to 2017
$1.5M
Lipid metabolites can both potentiate and treat alcoholic hepatitisU01AA026936 · NIAAA · UNIVERSITY OF LOUISVILLE · PI JOSHI-BARVE, SWATI, MCCLAIN, CRAIG J. · 2018 to 2022
$1.2M
Impaired methylation alters lipid droplet dynamics in liver and adipose tissue: Role in hepatic steatosisI01BX004053 · VA · OMAHA VA MEDICAL CENTER · PI KHARBANDA, KUSUM K. · 2019 to 2023
–
BLRD VA I01 BX002996BLRD VA I01 BX004053NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA020212NIAAA NIH HHS R01 AA023190NIAAA NIH HHS R01 AA023681NIAAA NIH HHS R01 AA024102NIAAA NIH HHS R01 AA026723NIAAA NIH HHS U01 AA021893NIAAA NIH HHS U01 AA021901NIAAA NIH HHS U01 AA022489NIAAA NIH HHS U01 AA026936NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

The symposium "Mechanisms, Biomarkers and Targets for Therapy in Alcohol-associated Liver Injury: From Genetics to Nutrition" was held at the 19th Congress of International Society for Biomedical Research on Alcoholism on September 13th, 2018 in Kyoto, Japan. The goal of the symposium was to discuss the importance of genetics and nutrition in alcoholic liver disease (ALD) development from mechanistic and therapeutic perspectives. The following is a summary of this session addressing the gene polymorphisms in ALD, the role of zinc in gut-liver axis perturbations associated with ALD, highlighting the importance of dietary fat in ALD pathogenesis, the hepatic n6 and n3 PUFA oxylipin pattern associated with ethanol-induced liver injury, and finally deliberating on new biomarkers for alcoholic hepatitis and their implications for diagnosis and therapy. This summary of the symposium will benefit junior and senior faculty currently investigating alcohol-induced organ pathology as well as undergraduate, graduate, and post-graduate students and fellows.

Indexed as

AnimalsBiomarkersDietDietary FatsHepatitis, AlcoholicHumansLipid MetabolismLiverLiver Diseases, AlcoholicMiceNutritional Physiological PhenomenaOxylipinsZincBiomarkersDietary FatsOxylipinsZinc3-hydroxypropyl-mercapturic acidacrolein-adductsalcoholic liver diseasedefensin 5genetic mutationslipid dropletsoxylipinsperilipinsphosphatidylcholinephosphatidylethanolaminePorphyromonas gingivalisresolvinszinczinc transporter

Identifiers

PMID31129175
PMCPMC7043088
OpenAlexW2945866930

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.