ArticleBMC genomics2019
A new reference genome for Sorghum bicolor reveals high levels of sequence similarity between sweet and grain genotypes: implications for the genetics of sugar metabolism.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 117 citations in OpenAlex.
- Revisiting the Molecular Roadmap for Sugar Crops: Genome Reading, Trait Writing and Variety Redesigning.Plant biotechnology journal · 2026Review
- Identification and Fine Mapping of a MYB-like Transcription Factor Regulating Yellow Grain inPlants (Basel, Switzerland) · 2026Article
- An updated molecular toolkit for genomics-assisted breeding of waxy sorghum [Sorghum bicolor (L.) Moench].Journal of applied genetics · 2026Article
- Pangenomic characterization and grain-development expression analysis of the OVATE gene family in sorghum.Frontiers in plant science · 2026Article
- Biotechnological and genetic innovations to enhance sorghum adaptation under climate change.Frontiers in plant science · 2026Review
- A haplotype-resolved genome assembly of Anoectochilus roxburghii.Scientific data · 2025Article
- Forage Crop Research in the Modern Age.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Salt stress-induced remodeling of sugar transport: a role for promoter alleles of SWEET13.Scientific reports · 2025Article
- Genome-wide association study and haplotype analyses reveal the genetic architecture of agronomic traits and sugars in sweet sorghum.Frontiers in genetics · 2025Article
- Abiotic stress responses in forage crops and grasses: the role of secondary metabolites and biotechnological interventions.Frontiers in plant science · 2025Review
- Sorghum as a monocot model for drought research.Frontiers in plant science · 2025Review
- Unveiling the Genomic Symphony: Identification Cultivar-Specific Genes and Enhanced Insights on Sweet Sorghum Genomes Through Comprehensive superTranscriptomic Analysis.Journal of molecular evolution · 2024Article
- Genomic resources, opportunities, and prospects for accelerated improvement of millets.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Characterization and Transcriptomic Analysis of Sorghum EIN/EIL Family and Identification of Their Roles in Internode Maturation.Plants (Basel, Switzerland) · 2024Article
- Dhurrin in Sorghum: Biosynthesis, Regulation, Biological Function and Challenges for Animal Production.Plants (Basel, Switzerland) · 2024Review
- Evolution of Einkorn wheat centromeres is driven by the mutualistic interplay of two LTR retrotransposons.Mobile DNA · 2024Article
- Telomere-to-telomere genome assembly of sorghum.Scientific data · 2024Article
- Genome-wide identification of the sorghum OVATE gene family and revelation of its expression characteristics in sorghum seeds and leaves.Scientific reports · 2024Article
- A complete assembly of the sorghum BTx623 reference genome.Plant communications · 2024Article
- Telomere-to-telomere genome assemblies of two Chinese Baijiu-brewing sorghum landraces.Plant communications · 2024Article
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Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe process of crop domestication often consists of two stages: initial domestication, where the wild species is first cultivated by humans, followed by diversification, when the domesticated species are subsequently adapted to more environments and specialized uses. Selective pressure to increase sugar accumulation in certain varieties of the cereal crop Sorghum bicolor is an excellent example of the latter; this has resulted in pronounced phenotypic divergence between sweet and grain-type sorghums, but the genetic mechanisms underlying these differences remain poorly understood.
resultsHere we present a new reference genome based on an archetypal sweet sorghum line and compare it to the current grain sorghum reference, revealing a high rate of nonsynonymous and potential loss of function mutations, but few changes in gene content or overall genome structure. We also use comparative transcriptomics to highlight changes in gene expression correlated with high stalk sugar content and show that changes in the activity and possibly localization of transporters, along with the timing of sugar metabolism play a critical role in the sweet phenotype.
conclusionsThe high level of genomic similarity between sweet and grain sorghum reflects their historical relatedness, rather than their current phenotypic differences, but we find key changes in signaling molecules and transcriptional regulators that represent new candidates for understanding and improving sugar metabolism in this important crop.
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