Evidence map›Paper›PMID 31154041›Full record

ReviewChest2019

Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study.

Diego J Maselli, Surya P Bhatt, Antonio Anzueto, Russell P Bowler, Dawn L DeMeo, Alejandro A Diaz, Mark T Dransfield, Ashraf Fawzy, Marilyn G Foreman, Nicola A Hanania and 11 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chest, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Pretraining on Chronic Lung Inflammatory Disease Datasets to Enhance Indeterminant Lung Cancer Classification using Masked Autoencoders.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Hypoxic Status in COPD and ARDS Patients: Impact on Lipid Signature.International journal of molecular sciences · 2025
    Article
  11. Alpha1-Antitrypsin in Lung Diseases: A Cross-Sectional Observational Study.International journal of molecular sciences · 2025
    Observational
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 12 institutions in 1 country.

Diego J MaselliDivision of Pulmonary Diseases and Critical Care, UT Health San Antonio, and South Texas Veterans Health System, San Antonio, TX.
Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.
Antonio AnzuetoDivision of Pulmonary Diseases and Critical Care, UT Health San Antonio, and South Texas Veterans Health System, San Antonio, TX.
Russell P BowlerDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Alejandro A DiazDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Mark T DransfieldDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.
Ashraf FawzyDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Marilyn G ForemanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Morehouse School of Medicine, Atlanta, GA.
Nicola A HananiaSection of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX.
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Victor KimDepartment of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, PA.
Gregory L KinneyDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO.
Nirupama PutchaDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Emily S WanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; VA Boston Healthcare System, Jamaica Plain, MA.
J Michael WellsDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.
Gloria E WestneyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Morehouse School of Medicine, Atlanta, GA.
Kendra A YoungDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI.
Barry J MakeDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO. Electronic address: makeb@NJHealth.org.
University of Colorado Denver · USUniversity of Alabama at Birmingham · USBrigham and Women's Hospital · USHarvard University · USMorehouse School of Medicine · USSouth Texas Veterans Health Care System · USBaylor College of Medicine · USJohns Hopkins Medicine · USJohns Hopkins University · USMichigan Medicine · USTemple University · USVA Boston Healthcare System · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Clinical Implications of Bronchiectasis in SmokersR01HL133137 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2017 to 2021
$2.9M
The association of allergic disease with clinical outcomes in COPD.K23HL123594 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PUTCHA, NIRUPAMA · 2015 to 2019
$1.0M
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseK23HL133438 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P. · 2016 to 2020
$921k
The Role of PGP in COPD-associated Pulmonary HypertensionK08HL123940 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2014 to 2018
$744k
NHLBI NIH HHS K08 HL123940NHLBI NIH HHS K23 HL123594NHLBI NIH HHS K23 HL133438NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL133137NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter, longitudinal analysis of > 10,000 subjects, including smokers with a ≥ 10 pack-year history with and without COPD and healthy never smokers. The goal was to characterize disease-related phenotypes and explore associations with susceptibility genes. The subjects were extensively phenotyped with the use of comprehensive symptom and comorbidity questionnaires, spirometry, CT scans of the chest, and genetic and biomarker profiling. The objective of this review was to summarize the major advances in the clinical epidemiology of COPD from the first 10 years of the COPDGene study. We highlight the influence of age, sex, and race on the natural history of COPD, and the impact of comorbid conditions, chronic bronchitis, exacerbations, and asthma/COPD overlap.

Indexed as

AgedCase-Control StudiesFemaleHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSmokingchronic bronchitiscomorbiditiesCOPDCOPDGeneepidemiologysex

Identifiers

PMID31154041
PMCPMC7198872
OpenAlexW2947566011

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.