Evidence map›Paper›PMID 31156621›Full record

ArticleFrontiers in immunology2019

SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response.

Namit Sharma, Marta Ponce, Savar Kaul, Zhongda Pan, Donna M Berry, Thomas Eiwegger, Catherine J McGlade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Namit SharmaProgram in Cell Biology and the Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Marta PonceProgram in Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Savar KaulProgram in Cell Biology and the Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Zhongda PanProgram in Cell Biology and the Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Donna M BerryProgram in Cell Biology and the Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Thomas EiweggerProgram in Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
Catherine J McGladeProgram in Cell Biology and the Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Binding of antigen to IgE-high affinity FcεRI complexes on mast cells and basophils results in the release of preformed mediators such as histamine and

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBasophilsBone Marrow CellsCells, CulturedChildChild, PreschoolCytokinesDinitrophenolsFemaleHumansImmunoglobulin EMaleMast CellsMiceMice, Inbred BALB CAdaptor Proteins, Signal TransducingCytokinesDinitrophenolsdinitrophenyl-human serum albumin conjugateImmunoglobulin EProto-Oncogene Proteins pp60(c-src)Receptors, IgESerum AlbuminSLA protein, humanSla protein, mousebasophilCbl-bIgE receptormast cellsignalingSLAP

Identifiers

PMID31156621
PMCPMC6529641

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.