Evidence map›Paper›PMID 31167408›Full record

ReviewNon-coding RNA2019

The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression.

Nithya Mudgapalli, Brianna P Shaw, Srinivas Chava, Kishore B Challagundla

Open access · goldAbstract readReview
In one paragraph

Review in Non-coding RNA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. miR-15a and miR-15b modulate natural killer and CD8Molecular therapy oncolytics · 2022
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nithya MudgapalliUNMC Summer Undergraduate Research Program, Omaha, NE 68198, USA. nmudgapalli@gmail.com.
Brianna P ShawUNMC Summer Undergraduate Research Program, Omaha, NE 68198, USA. brianna.shaw@unmc.edu.
Srinivas ChavaDepartment of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. srinivas.chava@unmc.edu.
Kishore B ChallagundlaDepartment of Biochemistry and Molecular Biology & The Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. kishore.challagundla@unmc.edu.
Research Experiences for Undergraduates · USUniversity of Nebraska Medical Center · US

Funding

Exosomic microRNAs and drug resistance in AML tumor microenvironmentK22CA197074 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CHALLAGUNDLA, KISHORE B. · 2016 to 2018
$465k
National Cancer Institute K22CA197074-01NCI NIH HHS K22 CA197074
6 · The paper itself

Abstract

The Transcribed-Ultra Conserved Regions (T-UCRs) are a class of novel non-coding RNAs that arise from the dark matter of the genome. T-UCRs are highly conserved between mouse, rat, and human genomes, which might indicate a definitive role for these elements in health and disease. The growing body of evidence suggests that T-UCRs contribute to oncogenic pathways. Neuroblastoma is a type of childhood cancer that is challenging to treat. The role of non-coding RNAs in the pathogenesis of neuroblastoma, in particular for cancer development, progression, and therapy resistance, has been documented. Exosmic non-coding RNAs are also involved in shaping the biology of the tumor microenvironment in neuroblastoma. In recent years, the involvement of T-UCRs in a wide variety of pathways in neuroblastoma has been discovered. Here, we present an overview of the involvement of T-UCRs in various cellular pathways, such as DNA damage response, proliferation, chemotherapy response,

Indexed as

biomarkersexosomesmetastasismicroRNAsMYCNneuroblastomaoncogenestherapy resistancetranscribed-ultra conserved regions

Identifiers

PMID31167408
PMCPMC6631508
OpenAlexW2949020864

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.