ArticleMedicine2019
Three-dimensional pseudocontinuous arterial spin labeling and susceptibility-weighted imaging associated with clinical progression in amnestic mild cognitive impairment and Alzheimer's disease.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Arterial Spin Labeling MRI in Alzheimer's Disease: A Systematic Review of Cerebral Perfusion Biomarkers.Journal of neuroimaging : official journal of the American Society of NeuroimagingPooled it
- A Multimodal MRI Study of the White Matter Microstructural and Hemodynamic Underpinnings of Cognitive Decline in Type 2 Diabetes Mellitus.Brain topography · 2026Article
- Cerebral blood flow based on 3D-ASL technology in the early detection of mild cognitive impairment in type 2 diabetic patients: a pilot study.Frontiers in endocrinology · 2025Article
- Cerebral perfusion and amyloidosis in the oldest-old.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review.Aging medicine (Milton (N.S.W)) · 2024Review
- Neuroimaging modalities in the detection of Alzheimer's disease-associated biomarkers.Psychoradiology · 2023Review
- The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer's Disease Spectrum: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Application of 3D-ASL in hemodynamic analysis and prognosis evaluation of vascular cognitive impairment.American journal of translational research · 2022Article
- Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling.Journal of neurology · 2021Article
- Brain hemodynamic changes in amnestic mild cognitive impairment measured by pulsed arterial spin labeling.Aging · 2020Article
- An update on magnetic resonance imaging markers in AD.Therapeutic advances in neurological disorders · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate the value of 3-dimensional pseudocontinuous arterial spin labeling (3D-pcASL) and susceptibility-weighted imaging (SWI) for the early disease-sensitive markers of conversion from amnestic MCI (aMCI) to Alzheimer disease (AD) in this process.
methodsForty patients with aMCI and AD respectively were recruited in the study, and 40 healthy subjects were taken as controls. Data were recorded using 3T MR scanner. We assessed the cerebral blood flow (CBF) in 11 different regions of interest, and counted number of microhemorrhages (MB) in 3 regions of brain lobes, bilateral basal ganglia/thalamus, and brain stem/cerebellum, and then investigated correlations between Montreal Cognitive Assessment (MoCA) scores, CBF, and susceptibility-weighted imaging (SWI) features in these 3 groups.
resultsThe results revealed that for AD patients, the MoCA scores and CBF values in frontal gray matter (FGM), occipital gray matter (OGM), temporal gray matter (TGM), parietal gray matter (PGM), hippocampus, anterior cingulate cortex (ACC), precuneus, posterior cingulate cortex (PCC), precuneus, basal ganglia and thalamus decreased compared with aMCI patients and control group, and significant difference was revealed among the 3 groups. While in cerebellum, statistical significance was only found between AD patients and control group. On SWI, the average numbers of hemorrhage in regions of lobes for AD patients were significantly higher than aMCI patients and control group. The same results occurred in the bilateral basal ganglia/thalamus. We further found the MoCA score was positively correlated with CBF, but negatively correlated with hypointense signal on SWI.
conclusion3D-pCASL and SWI have promising potential to be biomarkers for conversion from aMCI to AD in this process.
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