ArticleBlood advances2019
Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.
Open access · goldAbstract read
In one paragraph
Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- ATRA improves megakaryopoiesis in immune thrombocytopenia through up-regulating the HIF-1α/SPHK2/S1P pathway.Science advances · 2026Article
- Blood-borne sphingosine 1-phosphate maintains vascular resistance, blood pressure, and cardiac function in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature.Cardiovascular research · 2024Article
- Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation.Nature cardiovascular research · 2023Article
- Role of sphingosine 1-phosphate (S1P) in sepsis-associated intestinal injury.Frontiers in medicine · 2023Review
- Platelet-Derived S1P and Its Relevance for the Communication with Immune Cells in Multiple Human Diseases.International journal of molecular sciences · 2022Review
- The bone marrow niche from the inside out: how megakaryocytes are shaped by and shape hematopoiesis.Blood · 2022Review
- Occurrence and role of lung megakaryocytes in infection and inflammation.Frontiers in immunology · 2022Review
- Review
- Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner.Scientific reports · 2021Article
- Deletion of Mfsd2b impairs thrombotic functions of platelets.Nature communications · 2021Article
- Endothelial S1PCirculation research · 2021Article
- Milk and Egg Are Risk Factors for Adverse Effects of Capecitabine-Based Chemotherapy in Chinese Colorectal Cancer Patients.Integrative cancer therapiesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 6 institutions in 3 countries.
Hira NiaziINSERM U970, Paris Cardiovascular Research Centre, Paris, France.
Nesrine ZoghdaniINSERM U970, Paris Cardiovascular Research Centre, Paris, France.
Ludovic CoutyINSERM U970, Paris Cardiovascular Research Centre, Paris, France.
Alexandre LeuciDepartment of Medicine, Université Paris-Descartes, Sorbonne Paris Cité, Paris, France.
Anja NitzscheINSERM U970, Paris Cardiovascular Research Centre, Paris, France.ORCID 0000-0003-0567-6790
Maria L AllendeGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Boubacar MarikoINSERM U970, Paris Cardiovascular Research Centre, Paris, France.
Rameez IshaqINSERM Unité Mixte de Recherche 1170, Université Paris-Saclay & Gustave Roussy, Villejuif, France.
Yetki AslanINSERM, Hôpital Lariboisière-Centre Viggo Petersen, Paris, France.
Pierre Hadrien BeckerAssistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service de Biochimie, Le Kremlin Bicêtre, France.
Salomé L GazitINSERM U970, Paris Cardiovascular Research Centre, Paris, France.
Sonia Poirault-ChassacDepartment of Medicine, Université Paris-Descartes, Sorbonne Paris Cité, Paris, France.
Benoit DecoutureDepartment of Medicine, Université Paris-Descartes, Sorbonne Paris Cité, Paris, France.
Veronique BaudrieINSERM U970, Paris Cardiovascular Research Centre, Paris, France.
Erica De CandiaServizio Malattie Emorragiche e Trombotiche, Polo Oncologia ed Ematologia, Istituto di Medicina Interna, Università Cattolica del Sacro Cuore, Rome, Italy; and.ORCID 0000-0003-0942-2819
Mari KonoGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-2447-4350
Ammar BenarabINSERM U970, Paris Cardiovascular Research Centre, Paris, France.
Pascale GaussemDepartment of Medicine, Université Paris-Descartes, Sorbonne Paris Cité, Paris, France.ORCID 0000-0002-9139-2147
Pierre-Louis TharauxINSERM U970, Paris Cardiovascular Research Centre, Paris, France.ORCID 0000-0002-6062-5905
Jerold ChunNeuroscience Drug Discovery, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.ORCID 0000-0003-3964-0921
Sylvain ProvotINSERM, Hôpital Lariboisière-Centre Viggo Petersen, Paris, France.
Najet DebiliINSERM Unité Mixte de Recherche 1170, Université Paris-Saclay & Gustave Roussy, Villejuif, France.
Patrice TherondAssistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service de Biochimie, Le Kremlin Bicêtre, France.
Richard L ProiaGenetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-0456-1270
Christilla Bachelot-LozaDepartment of Medicine, Université Paris-Descartes, Sorbonne Paris Cité, Paris, France.
Eric CamererINSERM U970, Paris Cardiovascular Research Centre, Paris, France.ORCID 0000-0002-6271-7125
Délégation Paris 5 · FRInserm · FRNational Institutes of Health · USUniversité Paris-Sud · FRSanford Burnham Prebys Medical Discovery Institute · USUniversità Cattolica del Sacro Cuore · IT
Funding
Mouse Models of Novel Sphingolipid Biology and Disease MechanismsZIADK056014 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2025
$10.6MSphingolipid Biology and Regulation of MetabolismZIADK056018 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2022
$8.9MSphingolipid Biology of Inflammation and ImmunityZIADK056015 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PROIA, RICHARD · 2009 to 2021
$7.9MAbstract
The bioactive lipid mediator sphingosine 1-phosphate (S1P) was recently assigned critical roles in platelet biology: whereas S1P
Indexed as
Signal TransductionStem Cell NicheThrombopoiesisAnimalsBlood PlateletsLysophospholipidsMegakaryocytesMiceMice, KnockoutSphingosineSphingosine-1-Phosphate ReceptorsLysophospholipidsS1pr1 protein, mouseSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate Receptors
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.