ArticleJournal of experimental botany2019
The multi-allelic APRR2 gene is associated with fruit pigment accumulation in melon and watermelon.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 129 citations in OpenAlex.
- PpAPRR2 regulates chlorophyll biosynthesis and chloroplast development during early fruit development in peach.Plant cell reports · 2026Article
- Introgression line libraries in melon (Molecular breeding : new strategies in plant improvement · 2026Review
- Ancient DNA reveals early use of melons in China's Song dynasty.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genome-Wide Identification of theGenes · 2026Article
- The combined effects of Golden2-like 2 and Pseudo-Response Regulator 2 control the fruit pigmentation in pepper.The Plant journal : for cell and molecular biology · 2026Article
- Map-based cloning and functional validation of ClChlH governing yellow rind color in watermelon (Citrullus lanatus).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- An Allele of Glutamate Formiminotransferase Triggers 5-Methyl-Tetrahydrofolate-to-MeFox Conversion and Facilitates Folate Biofortification in Maize.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A melon (bioRxiv : the preprint server for biology · 2025Article
- Fine mapping and prediction of a candidate gene for wrinkled rind in melon (Cucumis melo L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The KNOX transcription factor ClSP activates ClAPRR2 to regulate dark green stripe formation in watermelon.Plant biotechnology journal · 2025Article
- Mapping and functional characterization of the golden fruit 1 (gf1) in melon (Cucumis melo L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Identification of Candidate Genes for Green Rind Color in Watermelon.Plants (Basel, Switzerland) · 2025Article
- Watermelon fruit metabolome gene discovery and its application in breeding: a review.Frontiers in plant science · 2025Review
- Uncovering the genetic mechanism of rind color trait in watermelon using fine mapping and comparative transcriptomic analysis.Frontiers in plant science · 2025Article
- Unveiling molecular mechanisms of pigment synthesis in gardenia (Food chemistry. Molecular sciences · 2024Article
- Map-based cloning revealed BhAPRR2 gene regulating the black peel formation of mature fruit in wax gourd (Benincasa hispida).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Mapping and transcriptomic profiling reveal that the KNAT6 gene is involved in the dark green peel colour of mature pumpkin fruit (Cucurbita maxima L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- The dominant white color trait of the melon fruit rind is associated with epicuticular wax accumulation.Planta · 2024Article
- Map-based cloning revealsMolecular breeding : new strategies in plant improvement · 2024Article
- The Y locus encodes a REPRESSOR OF PHOTOSYNTHETIC GENES protein that represses carotenoid biosynthesis via interaction with APRR2 in carrot.The Plant cell · 2024Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Color and pigment contents are important aspects of fruit quality and consumer acceptance of cucurbit crops. Here, we describe the independent mapping and cloning of a common causative APRR2 gene regulating pigment accumulation in melon and watermelon. We initially show that the APRR2 transcription factor is causative for the qualitative difference between dark and light green rind in both crops. Further analyses establish the link between sequence or expression level variations in the CmAPRR2 gene and pigment content in the rind and flesh of mature melon fruits. A genome-wide association study (GWAS) of young fruit rind color in a panel composed of 177 diverse melon accessions did not result in any significant association, leading to an earlier assumption that multiple genes are involved in shaping the overall phenotypic variation in this trait. Through resequencing of 25 representative accessions and allelism tests between light rind accessions, we show that multiple independent single nucleotide polymorphisms in the CmAPRR2 gene are causative of the light rind phenotype. The multi-haplotypic nature of this gene explains the lack of detection power obtained through genotyping by sequencing-based GWAS and confirms the pivotal role of this gene in shaping fruit color variation in melon. This study demonstrates the power of combining bi- and multi-allelic designs with deep sequencing, to resolve lack of power due to high haplotypic diversity and low allele frequencies. Due to its central role and broad effect on pigment accumulation in fruits, the APRR2 gene is an attractive target for carotenoid bio-fortification of cucurbit crops.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.