Evidence map›Paper›PMID 31175373›Full record

Observational studyDiabetologia2019

Early nerve fibre regeneration in individuals with type 1 diabetes after simultaneous pancreas and kidney transplantation.

Shazli Azmi, Maria Jeziorska, Maryam Ferdousi, Ioannis N Petropoulos, Georgios Ponirakis, Andrew Marshall, Uazman Alam, Omar Asghar, Andrew Atkinson, Wendy Jones and 4 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 4 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Shazli AzmiInstitute of Cardiovascular Sciences, University of Manchester and Central Manchester NHS Foundation Trust, Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK.
Maria JeziorskaInstitute of Cardiovascular Sciences, University of Manchester and Central Manchester NHS Foundation Trust, Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK.
Maryam FerdousiInstitute of Cardiovascular Sciences, University of Manchester and Central Manchester NHS Foundation Trust, Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK.
Ioannis N PetropoulosDepartment of Medicine, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, Qatar.
Georgios PonirakisDepartment of Medicine, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, Qatar.
Andrew MarshallDepartment of Clinical Neurophysiology, Central Manchester NHS Foundation Trust, Manchester, UK.
Uazman AlamDepartment of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Omar AsgharInstitute of Cardiovascular Sciences, University of Manchester and Central Manchester NHS Foundation Trust, Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK.
Andrew AtkinsonInstitute of Cardiovascular Sciences, University of Manchester and Central Manchester NHS Foundation Trust, Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK.
Wendy JonesInstitute of Cardiovascular Sciences, University of Manchester and Central Manchester NHS Foundation Trust, Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK.
Andrew J M BoultonInstitute of Cardiovascular Sciences, University of Manchester and Central Manchester NHS Foundation Trust, Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK.
Michael BrinesAraim Pharmaceuticals, Tarrytown, NY, USA.
Titus AugustineDepartment of Transplant and Endocrine Surgery, Central Manchester University Hospital NHS Foundation Trust, Manchester, UK.
Rayaz A MalikInstitute of Cardiovascular Sciences, University of Manchester and Central Manchester NHS Foundation Trust, Core Technology Facility, Grafton Street, Manchester, M13 9NT, UK. rayaz.a.malik@manchester.ac.uk.
Manchester University NHS Foundation Trust · GBUniversity of Manchester · GBWeill Cornell Medical College in Qatar · QAAraim Pharmaceuticals (United States) · USUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisThe study aimed to assess the impact on neuropathy of simultaneous pancreas and kidney transplantation (SPK) in individuals with type 1 diabetes.

methodsThis longitudinal observational study examined neuropathic symptoms, deficits, quantitative sensory testing, neurophysiology, corneal confocal microscopy and skin biopsy results in 32 healthy (non-diabetic) control participants, 29 individuals with type 1 diabetes and severe diabetic peripheral neuropathy [DPN] and 36 individuals with type 1 diabetes after SPK.

resultsFollowing SPK, HbA CONCLUSIONS/

interpretationSPK is associated with early and maintained small nerve fibre regeneration in the cornea and skin, followed by an improvement in neuropathic symptoms and peroneal nerve conduction velocity.

Indexed as

Nerve RegenerationAdultAgedBiopsyCorneaDiabetes Mellitus, Type 1Diabetic NeuropathiesFemaleHumansKidney Failure, ChronicKidney TransplantationLongitudinal StudiesMaleMicroscopy, ConfocalMiddle AgedNerve FibersTriglyceridesCorneal confocal microscopyDiabetic neuropathyPancreas and kidney transplantationSkin biopsy

Identifiers

PMID31175373
PMCPMC6647173
OpenAlexW2950792943

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.