Evidence map›Paper›PMID 31178690›Full record

ArticleFrontiers in molecular neuroscience2019

Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy.

Deborah Huyghe, Andrew R Denninger, Caroline M Voss, Pernille Frank, Ning Gao, Nicholas Brandon, Helle S Waagepetersen, Andrew D Ferguson, Menelas Pangalos, Peter Doig and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Deborah HuygheDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.
Andrew R DenningerMechanistic Biology & Profiling, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Boston, MA, United States.
Caroline M VossDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pernille FrankDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ning GaoMechanistic Biology & Profiling, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Boston, MA, United States.
Nicholas BrandonNeuroscience, IMED Biotech Unit, AstraZeneca, Boston, MA, United States.
Helle S WaagepetersenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Andrew D FergusonStructure & Biophysics, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Boston, MA, United States.
Menelas PangalosIMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom.
Peter DoigMechanistic Biology & Profiling, Discovery Sciences, IMED Biotech Unit, AstraZeneca, Boston, MA, United States.
Stephen J MossDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.
AstraZeneca (United States) · USUniversity of Copenhagen · DKTufts University · USAstraZeneca (United Kingdom) · GB

Funding

Modulation of KCC2 activity and the postnatal development of synaptic inhibitionR01NS101888 · NINDS · TUFTS UNIVERSITY BOSTON · PI DEEB, TAREK ZIAD, MOSS, STEPHEN J · 2017 to 2021
$2.3M
Dissecting Mechanisms of GABAB-GIRK Plasticity with PsychostimulantsR01DA037170 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOSS, STEPHEN J, SLESINGER, PAUL A · 2014 to 2018
$2.1M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1M
Deficits in KCC2 activity and the pathophysiology of Status EpilepticusR01NS087662 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2014 to 2018
$2.0M
Deficits in KCC2 activity and the pathophysiology of Autism spectrum disordersR21MH106954 · NIMH · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2015 to 2016
$454k
NIDA NIH HHS R01 DA037170NIMH NIH HHS R01 MH097446NIMH NIH HHS R21 MH106954NINDS NIH HHS R01 NS087662NINDS NIH HHS R01 NS101888
6 · The paper itself

Abstract

The astrocyte-specific enzyme glutamine synthetase (GS), which catalyzes the amidation of glutamate to glutamine, plays an essential role in supporting neurotransmission and in limiting NH

Indexed as

astrocytecAMP-dependent protein kinaseepilepsyglutamine synthetasephosphorylation

Identifiers

PMID31178690
PMCPMC6536897
OpenAlexW2946009460

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.