Evidence map›Paper›PMID 31180948›Full record

ArticleJournal of the Chinese Medical Association : JCMA2019

Magnesium-responsive genes are downregulated in diabetic patients after a three-month exercise program on a bicycle ergometer.

Yueh-Feng Chiang, Hsuan-Ying Chen, I-Te Lee, Li-Sheng Chien, Jui-Hua Huang, Martin Kolisek, Fu-Chou Cheng, Sen-Wei Tsai

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Journal of the Chinese Medical Association : JCMA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The Benefits of Nanosized Magnesium Oxide in FishAntioxidants (Basel, Switzerland) · 2023
    Article
  3. Review
  4. Towards a link between magnesium, exercise, and risk of type 2 diabetes mellitus.Journal of the Chinese Medical Association : JCMA · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Yueh-Feng ChiangDepartment of Orthopedics, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, ROC.
Hsuan-Ying ChenOrthopedics and Sports Medicine Laboratory, Changhua Christian Hospital, Changhua, Taiwan, ROC.
I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Li-Sheng ChienStem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Jui-Hua HuangStem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Martin KolisekInstitute of Veterinary-Physiology, Freies Universitat, Berlin, Germany.
Fu-Chou ChengStem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Sen-Wei TsaiDepartment of Physical Medicine and Rehabilitation, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan, ROC.
Taichung Veterans General Hospital · TWChanghua Christian Hospital · TWFreie Universität Berlin · DENational Chung Hsing University · TWNational Yang Ming Chiao Tung University · TWTaipei Tzu Chi Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise is an effective therapy for the management of diabetes because it helps regulate glucose and magnesium homeostasis. Nevertheless, the mechanisms by which exercise exerts effects on magnesium transport remain unclear. This study investigated the expression of genes encoding magnesium transporters (GMTs) after a three-month exercise program in diabetic patients.

methodsThis study was conducted with a within-subject pre-post design. A total of 15 adult patients with type 2 diabetes mellitus (T2DM) were recruited and underwent a three-month indoor bicycle exercise program. The expression of five GMTs (CNNM2, TRPM6, TRPM7, SLC41A1, and SLC41A3) was determined in blood samples. Relevant anthropometric values and biochemical parameters were also determined.

resultsAlthough the body weight and body mass index decreased after three months exercise, there were no significant differences. Fasting blood glucose, glycated hemoglobin (HbA1c), waist circumference, and magnesium levels decreased after the exercise program (p < 0.05). The expression of SLC41A1 and SLC41A3 were downregulated after exercise, but only CNNM2, TRPM6, and TRPM7 showed significantly decreased expression levels compared with those before the exercise program (p < 0.05).

conclusionThe three-month exercise program ameliorated blood glucose levels and downregulated the expression of magnesium-responsive genes in patients with T2DM.

Indexed as

Exercise TherapyBlood GlucoseCation Transport ProteinsDiabetes Mellitus, Type 2Down-RegulationExercise TestFemaleHumansMagnesiumMaleMembrane Transport ProteinsMiddle AgedProspective StudiesProtein Serine-Threonine KinasesTRPM Cation ChannelsBlood GlucoseCation Transport ProteinsCNNM2 protein, humanMagnesiumMembrane Transport ProteinsProtein Serine-Threonine KinasesTRPM6 protein, humanTRPM7 protein, humanTRPM Cation Channels

Identifiers

PMID31180948
OpenAlexW2949389426

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.