Evidence map›Paper›PMID 31185941›Full record

Observational studyBMC pregnancy and childbirth2019

Prevalence and profile of adverse drug reactions in high-risk pregnancy: a cohort study.

Kathlen Dayanne Lopes da Silva, Flávia Evelyn Medeiros Fernandes, Thiago de Lima Pessoa, Sara Iasmin Vieira Cunha Lima, Antônio Gouveia Oliveira, Rand Randall Martins

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Kathlen Dayanne Lopes da SilvaPharmacy Department, Federal University of Rio Grande do Norte (UFRN), Centro de Ciências da Saúde, Av. General Gustavo Cordeiro de Farias, Petrópolis, Natal, RN, 59012-570, Brazil.
Flávia Evelyn Medeiros FernandesUniversity Maternity Januário Cicco. Multiprofessional Residency in Health, UFRN, Natal, RN, Brazil.
Thiago de Lima PessoaUniversity Maternity Januário Cicco. Multiprofessional Residency in Health, UFRN, Natal, RN, Brazil.
Sara Iasmin Vieira Cunha LimaPostgraduate Program in Pharmaceutical Sciences, UFRN, Natal, RN, Brazil. sivclima@gmail.com.
Antônio Gouveia OliveiraPharmacy Department, Federal University of Rio Grande do Norte (UFRN), Centro de Ciências da Saúde, Av. General Gustavo Cordeiro de Farias, Petrópolis, Natal, RN, 59012-570, Brazil.
Rand Randall MartinsPharmacy Department, Federal University of Rio Grande do Norte (UFRN), Centro de Ciências da Saúde, Av. General Gustavo Cordeiro de Farias, Petrópolis, Natal, RN, 59012-570, Brazil.
Universidade Federal do Rio Grande do Norte · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCommonly used drugs in pregnant women include antihypertensives, hypoglycemic agents, analgesics, antimicrobials, antiemetics and antispasmodics but the use of medicines during pregnancy, especially in high-risk pregnancy, may be associated with high risk of adverse drug reactions (ADR). The objective of this study was to determine the risk of an adverse drug reaction in hospitalized high-risk pregnant women and the factors associated with their occurrence.

methodsThe study received IRB approval and all patients gave written informed consent. Observational cohort study conducted from September 2015 to November 2016 in 1070 pregnant women consecutively admitted to the high risk sector of the University Maternity Januário Cicco in Brazil. ADR were detected through daily active search. Risk factors for the occurrence of ADR were determined using multivariate logistic regression.

resultsThe mean age of the study population was 26.2 ± 7.2 years and gestational age was 31.2 ± 7.2 weeks. The average number of previous pregnancies was 2.4 ± 1.8 and 46.4% reported cases of previous abortion/miscarriage. ADR were observed in 10.7% of women. The main medicines involved, with the incidence rate of ADR per 100 prescriptions of the drug (IR), were parenteral scopolamine (IR 14.9%), methyldopa (IR 15.9%), insulin (IR 8.46%), oral scopolamine (IR 3.58%), captopril (IR 2.38%) and ceftriaxone (IR 18.4%). Multivariate analysis showed that only gestational age in weeks (odds-ratio 0.97, 95% confidence interval 0.95-0.98) was related to the occurrence of adverse reactions.

conclusionLower gestational age is a risk factor for high-risk pregnant women, increasing the likelihood of adverse reactions, with parenteral medications being those that have the highest potential risk of harm.

Indexed as

Drug-Related Side Effects and Adverse ReactionsPregnancy ComplicationsPregnancy, High-RiskAdultBrazilCohort StudiesFemaleHospitalizationHumansMedication Therapy ManagementPregnancyPregnancy OutcomePrevalenceRisk FactorsAdverse drug reactionHigh-risk pregnancyPregnancy

Identifiers

PMID31185941
PMCPMC6560812
OpenAlexW2949134686

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.