Evidence map›Paper›PMID 31190187›Full record

ReviewClinical and experimental medicine2019

Advances in liquid biopsy using circulating tumor cells and circulating cell-free tumor DNA for detection and monitoring of breast cancer.

Xiaofen Zhang, Shaoqing Ju, Xudong Wang, Hui Cong

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical and experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Circulating biomarkers for diagnosis and response to therapies in cancer patients.International review of cell and molecular biology · 2025
    Review
  4. Identification of circulating tumor cells captured by the FDA-cleared ParsortixJournal of experimental & clinical cancer research : CR · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Microfluidics for the Isolation and Detection of Circulating Tumor Cells.Advances in experimental medicine and biology · 2022
    Article
  10. Review
  11. Liquid Biopsy: A Family of Possible Diagnostic Tools.Diagnostics (Basel, Switzerland) · 2021
    Review
  12. Article
  13. Review
  14. Article
  15. Case report: 16-yr life history and genomic evolution of an ERCold Spring Harbor molecular case studies · 2020
    Article
  16. Review
  17. Review
  18. Review
  19. ctcRbase: the gene expression database of circulating tumor cells and microemboli.Database : the journal of biological databases and curation · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiaofen ZhangDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, China.ORCID http://orcid.org/0000-0002-3660-4557
Shaoqing JuDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Xudong WangDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Hui CongDepartment of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, China. huicjs@163.com.
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overview the progress of liquid biopsy using circulating tumor cells (CTCs) and circulating cell-free tumor DNA (cfDNA) to detect and monitor breast cancer. Based on numerous research efforts, the potential value of CTCs and cfDNA in the clinical aspects of cancer has become clear. With the development of next-generation sequencing analysis and newly developed technologies, many technical issues have been resolved, making liquid biopsy widely used in clinical practice. They can be powerful tools for dynamic monitoring of tumor progression and therapeutic efficacy. In the field of breast cancer, liquid biopsy is a research hot spot in recent years, playing a key role in monitoring breast cancer metastasis, predicting disease recurrence and assessing clinical drug resistance. Liquid biopsy has the advantages of noninvasive, high sensitivity, high specificity and real-time dynamic monitoring. Still application is far from reality, but the research and application prospects of CTCs and cfDNA in breast cancer are still worth exploring and discovering. This article reviews the main techniques and applications of CTCs and cfDNA in breast cancer.

Indexed as

Biomedical ResearchBreast NeoplasmsCirculating Tumor DNAFemaleHumansLiquid BiopsyNeoplastic Cells, CirculatingSensitivity and SpecificityCirculating Tumor DNABreast cancerCirculating cell-free tumor DNA (ctDNA)Circulating tumor cells (CTCs)Liquid biopsy

Identifiers

PMID31190187
OpenAlexW2950242238

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.