Statins × inflammation & biomarkers

SynthesisDrug design, development and therapy2019

Effect of pravastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials.

Xiangrong Shu et al.PubMed ↗Full text ↗Publisher ↗

  • Pravastatin treatmentlooks good hereHigher circulating adiponectin.Randomised, small.

What the trial testedrandomised · 595 people · 2019

Randomised vs controls

Probably raised circulating adiponectin

+0.63+0.17 to +1.09

Pravastatin treatment vs controls

As reported

difference 0.63, 95% CI 0.17–1.09

Who was studied, and how

595people with cardiovascular disease, in this paper

The trial randomly assignedassigned by chance

Pravastatin treatment
controls

Probably raised circulating adiponectin+0.63

randomised

the abstract, start to end

(weighted mean difference [WMD] =0.63 µg/mL; 95% CI, 0.17-1.09 µg/mL;

← favours treatmentfavours comparator →
could be chance
Circulating adiponectinPravastatin treatment vs controls
0.630.17–1.09
StatinsInflammation & biomarkers

Statins × inflammation & biomarkershelps?mixed

unlikelylikely
0.48not counted
← favours treatmentfavours comparator →
more certainless certain
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2 papers cite it

2019
2020
this paperpooled itcites it
Full record →Abstract, authors, funding and every citing paper · PMID 31190742