Evidence map›Paper›PMID 31197068›Full record

ArticleHaematologica2020

Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts.

Lea A Hampton-O'Neil, Charlotte E Severn, Stephen J Cross, Sonam Gurung, Catherine D Nobes, Ashley M Toye

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Macrophages: key players in erythrocyte turnover.Hematology, transfusion and cell therapy
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lea A Hampton-O'NeilSchool of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol.
Charlotte E SevernSchool of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol.
Stephen J CrossSchool of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol.
Sonam GurungSchool of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol.
Catherine D NobesSchool of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol.
Ashley M ToyeSchool of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol ash.m.toye@bristol.ac.uk.
University of Bristol · GBNational Institute for Health Research · GB

Funding

Department of Health NIHR-BTRU-2015-10032Wellcome TrustWellcome Trust 105385/Z/14/Z
6 · The paper itself

Abstract

Erythropoiesis is one of the most efficient cellular processes in the human body producing approximately 2.5 million red blood cells every second. This process occurs in a bone marrow niche comprised of a central resident macrophage surrounded by differentiating erythroblasts, termed an erythroblastic island. It is not known what initially attracts the macrophage to erythroblasts to form these islands. The ephrin/Eph receptor family are known to regulate heterophilic cell-cell adhesion. We find that human VCAM1

Indexed as

EphrinsErythroblastsErythropoiesisHumansMacrophagesReceptor, EphB4Receptors, Eph FamilyEPHB4 protein, humanEPHB6 protein, humanEphrinsReceptor, EphB4Receptors, Eph Family

Identifiers

PMID31197068
PMCPMC7109712
OpenAlexW2949706015

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.