Evidence mapPaperPMID 31197613Full record

ReviewCurrent obesity reports2019

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery.

Jean Debédat, Karine Clément, Judith Aron-Wisnewsky

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current obesity reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07643376 (Evaluation of Postoperative Metabolic Parameters, Intestinal Permeability and Gastrointestinal Symptoms in Body Weight Management After Laparoscopic Sleeve Gastrectomy), which is not on this map. Cited by 79 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 4 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07643376 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of Postoperative Metabolic Parameters, Intestinal Permeability and Gastrointestinal Symptoms in Body Weight Management After Laparoscopic Sleeve Gastrectomy

TypeobservationalSponsorToros UniversityRan2026 to 2027Enrolled40ConditionsObesity, Morbid, Bariatric Surgery, Intestinal Permeability, Gastrointestinal SymptomsArmsClinical and Biochemical Assessment
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. THE INTESTINAL MICROBIOME IN PATIENTS UNDERGOING BARIATRIC SURGERY: A SYSTEMATIC REVIEW.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022 · on this map
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jean DebédatINSERM, NutriOmics Research Unit, Sorbonne Université, Paris, France.
Karine ClémentINSERM, NutriOmics Research Unit, Sorbonne Université, Paris, France. karine.clement@inserm.fr.
Judith Aron-WisnewskyINSERM, NutriOmics Research Unit, Sorbonne Université, Paris, France. judith.aron-wisnewsky@psl.aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewIn this review, we summarize what is currently described in terms of gut microbiota (GM) dysbiosis modification post-bariatric surgery (BS) and their link with BS-induced clinical improvement. We also discuss how the major inter-individual variability in terms of GM changes could impact the clinical improvements seen in patients. RECENT

findingsThe persisting increase in severe obesity prevalence has led to the subsequent burst in BS number. Indeed, it is to date the best treatment option to induce major and sustainable weight loss and metabolic improvement in these patients. During obesity, the gut microbiota displays distinctive features such as low microbial gene richness and compositional and functional alterations (termed dysbiosis) which have been associated with low-grade inflammation, increased body weight and fat mass, as well as type-2 diabetes. Interestingly, GM changes post-BS is currently being proposed as one the many mechanism explaining BS beneficial clinical outcomes. BS enables partial rescue of GM dysbiosis observed during obesity. Some of the GM characteristics modified post-BS (composition in terms of bacteria and functions) are linked to BS beneficial outcomes such as weight loss or metabolic improvements. Nevertheless, the changes in GM post-BS display major variability from one patient to the other. As such, further large sample size studies associated with GM transfer studies in animals are still needed to completely decipher the role of GM in the clinical improvements observed post-surgery.

Indexed as

AnimalsBacteriaBariatric SurgeryDiabetes Mellitus, Type 2DysbiosisGastrectomyGastrointestinal MicrobiomeHumansInflammationObesityObesity, MorbidPostoperative PeriodTreatment OutcomeWeight GainWeight LossAdjustable gastric bandingAkkermansia muciniphilaBacteroidetesBariatric surgeryBMIFaecalibacterium prausnitziiFirmicutesGammaproteobacteriaGut microbiotaHbA1cIlluminaMetabolismMetagenomicsMicrobial gene richnessObesityProteobacteriaRemissionRichnessRoseburia intestinalisRoux-en-Y gastric bypassSleeve gastrectomyType-2 diabetes

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.