Evidence map›Paper›PMID 31198549›Full record

ArticleClinical kidney journal2019

Acute effects of haemodialysis on circulating microparticles.

Philip de Laval, Fariborz Mobarrez, Tora Almquist, Liina Vassil, Bengt Fellström, Inga Soveri

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Philip de LavalDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Fariborz MobarrezDepartment of Medicine, Karolinska Institutet, Unit of Rheumatology, Karolinska University Hospital, Solna, Sweden.
Tora AlmquistDivision of Nephrology, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Liina VassilDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Bengt FellströmDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Inga SoveriDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Uppsala University · SEKarolinska Institutet · SEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicroparticles (MPs) are small cell membrane-derived vesicles regarded as both biomarkers and mediators of biological effects. Elevated levels of MPs have previously been associated with endothelial dysfunction and predict cardiovascular death in patients with end-stage renal disease. The objective of this study was to measure change in MP concentrations in contemporary haemodialysis (HD).

methodsBlood was sampled from 20 consecutive HD patients before and 1 h into the HD session. MPs were measured by flow cytometry and phenotyped based on surface markers.

resultsConcentrations of platelet (CD41

conclusionDialysis triggers release of MPs of various origins with marked differences between high-flux and low-flux dialysers. The MPs carry surface molecules that could possibly influence coagulation, inflammation, oxidative stress and endothelial dysfunction. The clinical impact of these findings remains to be established in future studies.

Indexed as

chronic kidney diseasehaemodialysisKlothomicroparticlesRAGE

Identifiers

PMID31198549
PMCPMC6543976
OpenAlexW2899279275

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.