Evidence map›Paper›PMID 31201630›Full record

ArticleDoklady. Biochemistry and biophysics2019

Dipeptide Mimetic of the BDNF Loop 4 Possesses Analgetic Activity.

T A Gudasheva, M A Konstantinopolsky, A V Tarasiuk, L G Kolik, S B Seredenin

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

T A GudashevaZakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, 125315, Moscow, Russia. tata-sosnovka@mail.ru.
M A KonstantinopolskyZakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, 125315, Moscow, Russia.
A V TarasiukZakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, 125315, Moscow, Russia.
L G KolikZakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, 125315, Moscow, Russia.
S B SeredeninZakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, 125315, Moscow, Russia.
Institute of Pharmacology Russian Academy of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. When administered systemically, it exhibited neuroprotective, antidepressant, and antidiabetic activities and stimulated neurogenesis and synaptogenesis. In this study, we established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5-48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.

Indexed as

AnalgesicsBrain-Derived Neurotrophic FactorDipeptidesPeptidomimeticsAnimalsHumansMaleProtein Structure, SecondaryRatsAnalgesicsBrain-Derived Neurotrophic FactorDipeptidesPeptidomimetics

Identifiers

PMID31201630
OpenAlexW2947987190

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.