Evidence map›Paper›PMID 31207254›Full record

ReviewNeuroscience and biobehavioral reviews2019

Gene-by-environment interactions in Alzheimer's disease and Parkinson's disease.

Amy R Dunn, Kristen M S O'Connell, Catherine C Kaczorowski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Article
  10. A comprehensive guide to genomeZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amy R DunnThe Jackson Laboratory, Bar Harbor, ME, 04609, USA. Electronic address: amy.dunn@jax.org.
Kristen M S O'ConnellThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Catherine C KaczorowskiThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.

Funding

Gene x Environment Interactions in Hypothalamic Dysfunction in Alzheimer's DiseaseRF1AG059778 · NIA · JACKSON LABORATORY · PI KACZOROWSKI, CATHERINE COOK, O'CONNELL, KRISTEN M · 2018 to 2020
$4.3M
Modulation of AgRP Neuronal Excitability: Role of Diet and Body WeightR01DK102918 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI O'CONNELL, KRISTEN M · 2014 to 2018
$2.0M
NIA NIH HHS RF1 AG059778NIDDK NIH HHS R01 DK102918
6 · The paper itself

Abstract

Diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) arise from complex interactions of genetic and environmental factors, with genetic variants regulating individual responses to environmental exposures (i.e. gene-by-environment interactions). Identifying gene-by-environment interactions will be critical to fully understanding disease mechanisms and developing personalized therapeutics, though these interactions are still poorly understood and largely under-studied. Candidate gene approaches have shown that known disease risk variants often regulate response to environmental factors. However, recent improvements in exposome- and genome-wide association and interaction studies in humans and mice are enabling discovery of novel genetic variants and pathways that predict response to a variety of environmental factors. Here, we highlight recent approaches and ongoing developments in human and rodent studies to identify genetic modulators of environmental factors using AD and PD as exemplars. Identifying gene-by-environment interactions in disease will be critical to developing personalized intervention strategies and will pave the way for precision medicine.

Indexed as

Alzheimer DiseaseExposomeGene-Environment InteractionGenome-Wide Association StudyParkinson DiseaseAnimalsHumansAlzheimer’s diseaseExposomeGene-EnvironmentGenetic reference panelGenomeParkinson’s disease

Identifiers

PMID31207254
PMCPMC6700747

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.