Evidence map›Paper›PMID 31207916›Full record

ArticleInternational journal of molecular sciences2019

Mechanisms Underlying Spontaneous Action Potential Generation Induced by Catecholamine in Pulmonary Vein Cardiomyocytes: A Simulation Study.

Shohei Umehara, Xiaoqiu Tan, Yosuke Okamoto, Kyoichi Ono, Akinori Noma, Akira Amano, Yukiko Himeno

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shohei UmeharaDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan. shoumezoo@gmail.com.
Xiaoqiu TanInstitute of Cardiovascular Research, Southwest Medical University, Luzhou 640000, China. tanxiaoqiu@swmu.edu.cn.
Yosuke OkamotoDepartment of Cell Physiology, Graduate School of Medicine, Akita University, Akita 010-8543, Japan. okamoto@med.akita-u.ac.jp.
Kyoichi OnoDepartment of Cell Physiology, Graduate School of Medicine, Akita University, Akita 010-8543, Japan. onok@med.akita-u.ac.jp.
Akinori NomaDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan. noma@sk.ritsumei.ac.jp.
Akira AmanoDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan. a-amano@fc.ritsumei.ac.jp.
Yukiko HimenoDepartment of Bioinformatics, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan. hime@fc.ritsumei.ac.jp.ORCID 0000-0002-6858-8475
Ritsumeikan University · JPAkita University · JPSouthwest Medical University · CN

Funding

JSPS KAKENHI (Grant-in-Aid for Young Scientists (B)) JP16K18996
6 · The paper itself

Abstract

Cardiomyocytes and myocardial sleeves dissociated from pulmonary veins (PVs) potentially generate ectopic automaticity in response to noradrenaline (NA), and thereby trigger atrial fibrillation. We developed a mathematical model of rat PV cardiomyocytes (PVC) based on experimental data that incorporates the microscopic framework of the local control theory of Ca

Indexed as

Action PotentialsModels, TheoreticalAnimalsCalcium SignalingCatecholaminesInositol 1,4,5-Trisphosphate ReceptorsMyocytes, CardiacPulmonary VeinsRatsReceptors, AdrenergicRyanodine Receptor Calcium Release ChannelSodium-Calcium ExchangerCatecholaminesInositol 1,4,5-Trisphosphate ReceptorsReceptors, AdrenergicRyanodine Receptor Calcium Release ChannelSodium-Calcium ExchangerautomaticityInsP3RIP3rat pulmonary vein cardiac myocyteα1- and β1-adrenoceptor

Identifiers

PMID31207916
PMCPMC6628582
OpenAlexW2953146494

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.