Evidence map›Paper›PMID 31209359›Full record

ArticleCell death and differentiation2020

Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis.

Dingyu Wang, Jiashuo Zheng, Qiongyuan Hu, Cheng Zhao, Qianyue Chen, Peiliang Shi, Qin Chen, Yujie Zou, Dayuan Zou, Qiyao Liu and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. Review: the role of GSDMD in sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Pooled it
  2. Article
  3. Article
  4. Role of PANoptosis in intestinal diseases and its therapeutic implications.Journal of molecular medicine (Berlin, Germany) · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. PANoptosis: potential new targets and therapeutic prospects in digestive diseases.Apoptosis : an international journal on programmed cell death · 2025
    Review
  10. Article
  11. Review
  12. [Mechanisms of pyroptosis in metabolic diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Dingyu Wang *State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China.
Jiashuo Zheng *Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 210000, Nanjing, China.
Qiongyuan HuResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 210000, Nanjing, China.
Cheng ZhaoResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 210000, Nanjing, China.
Qianyue ChenState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China.
Peiliang ShiState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China.
Qin ChenState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China.
Yujie ZouState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China.
Dayuan ZouState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China.
Qiyao LiuState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China.
Jingwen PeiState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China.
Xiuwen WuResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 210000, Nanjing, China.
Xiang GaoState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China. gaoxiang@nju.edu.cn.
Jianan RenResearch Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 210000, Nanjing, China. jiananr@gmail.com.
Zhaoyu LinState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 210000, Nanjing, China. linzy@nju.edu.cn.
Nanjing University · CNState Key Laboratory of Pharmaceutical BiotechnologyNanjing General Hospital of Nanjing Military Command · CNModel Animal Research Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypomagnesemia is a significant risk factor for critically ill patients to develop sepsis, a life-threatening disease with a mortality rate over 25%. Our clinic data analysis showed that hypomagnesemia is associated with a decreased monocyte count in septic patients. At the cellular level, we found that Mg

Indexed as

AnimalsCells, CulturedGasderminsHEK293 CellsHumansIntracellular Signaling Peptides and ProteinsLipopolysaccharidesMagnesiumMaleMiceMice, Inbred C57BLPhosphate-Binding ProteinsPyroptosisSepsisGasderminsGSDMD protein, humanIntracellular Signaling Peptides and ProteinsLipopolysaccharidesMagnesiumPhosphate-Binding Proteins

Identifiers

PMID31209359
PMCPMC7206066
OpenAlexW2952514272

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.