Evidence map›Paper›PMID 31209505›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2019

Activation of the Notch signaling pathway disturbs the CD4

Xuewei Yin, Bin Liu, Huixia Wei, Shanshan Wu, Lijie Guo, Furu Xu, TingTing Liu, Hongsheng Bi, Dadong Guo

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xuewei YinPostgraduate Student of the Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250002, China.
Bin LiuPostgraduate Student of the Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250002, China.
Huixia WeiPostgraduate Student of the Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250002, China.
Shanshan WuSchool of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, 250002, China.
Lijie GuoCollege of Life Sciences, Qingdao Agricultural University, Qingdao, 266109, China.
Furu XuSchool of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, 250002, China.
TingTing LiuAffiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250002, China.
Hongsheng BiShandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Eye Institute of Shandong University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan, 250002, China.
Dadong GuoShandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Eye Institute of Shandong University of Traditional Chinese Medicine, No. 48#, Yingxiongshan Road, Jinan, 250002, China. dadonggene@163.com.ORCID http://orcid.org/0000-0002-1712-0055
Shandong University of Traditional Chinese Medicine · CNQingdao Agricultural University · CNShandong Shierming Eye Hospital · CN

Funding

Development Project of Science and Technology of Traditional Chinese Medicine of Shandong Province 2015-145Key Development & Research Program of Shandong Province 2016GGB14291National Natural Science Foundation of China 81873163Natural Science Foundation of Shandong Province ZR2017LH042the Development Project of Medicine and Health Science Technology of Shandong Province 2013WS0251
6 · The paper itself

Abstract

OBJECTIVE AND

designThe present study aimed to investigate the relationship between the disturbed balance of CD4

methodsAn EAU rat model was induced in Lewis rats, and pathology analysis was performed by hematoxylin and eosin (H&E) staining. CD4

resultsThe pathological results showed that inflammatory cell infiltration occurred in ocular tissues in EAU rats. The CD4

conclusionThe activation of the Notch signaling pathway can regulate Th17 and Treg cell differentiation, disrupt the CD4

Indexed as

AnimalsAutoimmune DiseasesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationDisease Models, AnimalFemaleGene Expression ProfilingInflammationInterleukin-10Interleukin-17Intracellular Signaling Peptides and ProteinsMembrane ProteinsRatsRats, Inbred LewReceptor, Notch1delta proteinIl17a protein, ratInterleukin-10Interleukin-17Intracellular Signaling Peptides and ProteinsMembrane ProteinsNotch1 protein, ratReceptor, Notch1Experimental autoimmune uveitisNotch signaling pathwayRegulatory T cellT helper 17 cell

Identifiers

PMID31209505
OpenAlexW2949464629

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.