Evidence map›Paper›PMID 31211956›Full record

ReviewJournal of molecular and cellular cardiology2019

Epigenetics and vascular diseases.

Matthew S Stratton, Floriana Maria Farina, Leonardo Elia

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The Epigenome in Atherosclerosis.Handbook of experimental pharmacology · 2022
    Article
  14. DNA Methylation Aberrant in Atherosclerosis.Frontiers in pharmacology · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew S StrattonDepartment of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, United States of America. Electronic address: matthew.stratton@osumc.edu.
Floriana Maria FarinaHumanitas Clinical and Research Center, Via Manzoni 113, 20089 Rozzano, MI, Italy; Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy.
Leonardo EliaHumanitas Clinical and Research Center, Via Manzoni 113, 20089 Rozzano, MI, Italy; Department of Molecular and Translational Medicine, University of Brescia, Italy. Electronic address: leonardo.elia@unibs.it.

Funding

BRD4, a Crucial Positive Regulator of Aging-Associated Diastolic DysfunctionK01AG056848 · NIA · OHIO STATE UNIVERSITY · PI STRATTON, MATTHEW · 2018 to 2022
$566k
NIA NIH HHS K01 AG056848
6 · The paper itself

Abstract

Cardiovascular disease remains the number one cause of death and disability worldwide despite significant improvements in diagnosis, prevention, and early intervention efforts. There is an urgent need for improved understanding of cardiovascular processes responsible for disease development in order to develop more effective therapeutic strategies. Recent knowledge gleaned from the study of epigenetic mechanisms in the vasculature has uncovered new potential targets for intervention. Herein, we provide an overview of epigenetic mechanism, and review recent findings related to epigenetics in vascular diseases, highlighting classical epigenetic mechanism such as DNA methylation and histone modification as well as the newly discovered non-coding RNA mechanisms.

Indexed as

Epigenesis, GeneticGene Expression RegulationGenetic Predisposition to DiseaseAnimalsChromatin Assembly and DisassemblyDisease ManagementDNA MethylationGenetic Association StudiesHistonesHumansPhenotypeProtein Processing, Post-TranslationalRNA, UntranslatedVascular DiseasesHistonesRNA, UntranslatedCardiovascular diseasesDNA methylationHistone modificationsLong non-coding RNAsmicroRNAs

Identifiers

PMID31211956
PMCPMC6757326

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.