Evidence map›Paper›PMID 31212856›Full record

ReviewBehavioral sciences (Basel, Switzerland)2019

Speech-Stimulating Substances in Autism Spectrum Disorders.

María Andrea Castillo, Kendy Eduardo Urdaneta, Neomar Semprún-Hernández, Anna Lisa Brigida, Nicola Antonucci, Stephen Schultz, Dario Siniscalco

Abstract readReview
In one paragraph

Review in Behavioral sciences (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Stem Cell-Derived Exosomes in Autism Spectrum Disorder.International journal of environmental research and public health · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

María Andrea CastilloResearch Division, Autism Immunology Unit of Maracaibo, Maracaibo 4001, Venezuela. mandicb0@gmail.com.ORCID 0000-0003-2312-8157
Kendy Eduardo UrdanetaResearch Division, Autism Immunology Unit of Maracaibo, Maracaibo 4001, Venezuela. kurdanetag@gmail.com.
Neomar Semprún-HernándezResearch Division, Autism Immunology Unit of Maracaibo, Maracaibo 4001, Venezuela. neomar.semprun@gmail.com.
Anna Lisa BrigidaItalian Group for Studying Autism-GISA, 25018 Brescia, Italy. brigida.annalisa@gmail.com.
Nicola AntonucciBiomedical Centre for Autism Research and Treatment, 70126 Bari, Italy. info@antonucci.eu.
Stephen SchultzDepartment of Cellular and Integrative Physiology, School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA. stevendri0629@gmail.com.
Dario SiniscalcoDepartment of Experimental Medicine, University of Campania, 80138 Napoli, Italy. dariosin@uab.edu.ORCID 0000-0002-3779-2596

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is characterized by the core domains of persistent deficits in social communication and restricted-repetitive patterns of behaviors, interests, or activities. A heterogeneous and complex set of neurodevelopmental conditions are grouped in the spectrum. Pro-inflammatory events and immune system dysfunctions are cellular and molecular events associated with ASD. Several conditions co-occur with ASD: seizures, gastro-intestinal problems, attention deficit, anxiety and depression, and sleep problems. However, language and speech issues are key components of ASD symptoms current therapies find difficult to face. Several speech-stimulating substances have been shown to be effective in increasing speech ability in ASD subjects. The need for large clinical trials to determine safety and efficacy is recommended.

Indexed as

autism spectrum disorderlanguagenutritionspeech

Identifiers

PMID31212856
PMCPMC6616660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.