Evidence mapPaperPMID 31214029Full record

ReviewFrontiers in pharmacology2019

Analysis of Patents Issued in China for Antihyperglycemic Therapies for Type 2 Diabetes Mellitus.

Wei Zhu, Wen Huang, Zhiqiang Xu, Mengda Cao, Qiaoli Hu, Chen Pan, Miao Guo, Ji-Fu Wei, Hongyu Yuan

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. The Effect of Chilgoza Pine Nut (Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei ZhuResearch Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wen HuangDepartment of GCP Office, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Zhiqiang XuResearch Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Mengda CaoResearch Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Qiaoli HuResearch Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chen PanSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Miao GuoResearch Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ji-Fu WeiResearch Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hongyu YuanResearch Division of Clinical Pharmacology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is prevalent, with a dramatic increase in recent years. Moreover, its microvascular and macrovascular complications cause significant societal issues. The demand for new and effective antidiabetic therapies grows with each passing day and motivates organizations and individuals to pay more attention to such products. In this article, we focused on oral antihyperglycemic drugs patented in China and introduced them according to their antihyperglycemic mechanisms. By searching the website of State Intellectual Property Office of the People's Republic of China (http://www.sipo.gov.cn), 2,500 antihyperglycemic patents for T2DM were identified and analyzed. These consisted of 4 patents for derivatives of herbal extracts (0.2%), 162 patents for herbal extracts (6.5%), 61 compositions for traditional Chinese medicine (TCM) (2.4%), 2,263 patents for synthetic compounds (90.5%), and 10 (0.4%) patents of the combination of synthetic compounds and TCM. As the most common drugs for diabetes mellitus, synthetic compounds can also be classified into several categories according to their working mechanisms, such as insulin secretion promotor agents, insulin sensitizer agents, α-glucosidase inhibitors, and so forth. This article discussed the chemical structure, potential antihyperglycemic mechanism of these antihyperglycemic drugs in patents in China.

Indexed as

antihyperglycemicpatentreviewtherapytype 2 diabetes mellitus

Identifiers

PMID31214029
PMCPMC6556973

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.