Evidence map›Paper›PMID 31214184›Full record

ArticleFrontiers in immunology2019

T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During

Matthias Hose, Anne Günther, Hanna Abberger, Salina Begum, Marek Korencak, Katrin A Becker, Jan Buer, Astrid M Westendorf, Wiebke Hansen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Acid Sphingomyelinase Deficiency: A Clinical and Immunological Perspective.International journal of molecular sciences · 2021
    Review
  6. Article
  7. mRNA Expression ofInternational journal of molecular sciences · 2021
    Article
  8. Review
  9. Glycosphingolipids and Infection. Potential New Therapeutic Avenues.Frontiers in cell and developmental biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Matthias HoseInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Anne GüntherInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Hanna AbbergerInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Salina BegumInstitute of Molecular Biology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Marek KorencakInstitute for HIV Research, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Katrin A BeckerInstitute of Molecular Biology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Jan BuerInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Astrid M WestendorfInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Wiebke HansenInstitute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DEInstitute of Molecular Biology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enzyme acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and is thereby involved in several cellular processes such as differentiation, proliferation, and apoptosis in different cell types. However, the function of ASM in T cells is still not well characterized. Here, we used T cell-specific ASM overexpressing mice (t-ASM/CD4cre) to clarify the impact of cell-intrinsic ASM activity on T cell function

Indexed as

AnimalsCell DifferentiationCells, CulturedForkhead Transcription FactorsHumansLymphocyte ActivationMalariaMiceParasitemiaPlasmodium yoeliiReceptors, Antigen, T-CellSignal TransductionSphingomyelin PhosphodiesteraseT-Lymphocytes, RegulatoryUp-RegulationForkhead Transcription FactorsFOXP3 protein, humanReceptors, Antigen, T-CellSphingomyelin Phosphodiesteraseacid sphingomyelinasemalariasphingolipidsT cell activationT cells

Identifiers

PMID31214184
PMCPMC6554418
OpenAlexW2946351658

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.