Evidence map›Paper›PMID 31216233›Full record

ArticleMolecular biology of the cell2019

Lowe syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in

Alexandre Luscher, Florian Fröhlich, Caroline Barisch, Clare Littlewood, Joe Metcalfe, Florence Leuba, Anita Palma, Michelle Pirruccello, Gianni Cesareni, Massimiliano Stagi and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Alexandre LuscherDepartment of Biochemistry, Faculty of Science, University of Geneva, 1211 Geneva-4, Switzerland.
Florian FröhlichDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Caroline BarischDepartment of Biochemistry, Faculty of Science, University of Geneva, 1211 Geneva-4, Switzerland.
Clare LittlewoodDepartment of Cellular and Molecular Physiology, University of Liverpool, L69 3BX Liverpool, United Kingdom.
Joe MetcalfeDepartment of Cellular and Molecular Physiology, University of Liverpool, L69 3BX Liverpool, United Kingdom.
Florence LeubaDepartment of Biochemistry, Faculty of Science, University of Geneva, 1211 Geneva-4, Switzerland.
Anita PalmaDepartment of Biology, University of Rome, 00133 Rome, Italy.
Michelle PirruccelloDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Gianni CesareniDepartment of Biology, University of Rome, 00133 Rome, Italy.
Massimiliano StagiDepartment of Cellular and Molecular Physiology, University of Liverpool, L69 3BX Liverpool, United Kingdom.
Tobias C WaltherDepartment of Genetics and Complex Diseases, Harvard School of Public Health, and Department of Cell Biology, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115.
Thierry SoldatiDepartment of Biochemistry, Faculty of Science, University of Geneva, 1211 Geneva-4, Switzerland.
Pietro De CamilliDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Laura E SwanDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Howard Hughes Medical Institute · USUniversity of Geneva · CHUniversity of Liverpool · GB

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0M
Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI ANGUS C. NAIRN, Kenneth Robert WILLIAMS · 2004 to 2026
$37.1M
MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLINGR01NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 1997 to 2021
$4.7M
Molecular Mechanisms in Synaptic Vesicle RecyclingR37NS036251 · NINDS · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 2010 to 2016
$2.7M
OCRL and the pathogenesis of Lowe Syndrome and Dent DiseaseR01DK082700 · NIDDK · YALE UNIVERSITY · PI DE CAMILLI, PIETRO · 2009 to 2016
$2.4M
Medical Research Council MR/N010035/1NIDA NIH HHS P30 DA018343NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK082700NINDS NIH HHS R01 NS036251NINDS NIH HHS R37 NS036251Wellcome TrustWellcome Trust 105616/Z/14/Z
6 · The paper itself

Abstract

Mutations of the inositol 5-phosphatase OCRL cause Lowe syndrome (LS), characterized by congenital cataract, low IQ, and defective kidney proximal tubule resorption. A key subset of LS mutants abolishes OCRL's interactions with endocytic adaptors containing F&H peptide motifs. Converging unbiased methods examining human peptides and the unicellular phagocytic organism

Indexed as

Amino Acid SequenceAnimalsDictyosteliumEndocytosisEndosomesGuanine Nucleotide Exchange FactorsHumansInositol Polyphosphate 5-PhosphatasesKineticsMembranesMutationOculocerebrorenal SyndromePhosphoric Monoester HydrolasesPinocytosisProtein BindingVacuolesGuanine Nucleotide Exchange FactorsInositol Polyphosphate 5-PhosphatasesOCRL protein, humanPhosphoric Monoester Hydrolases

Identifiers

PMID31216233
PMCPMC6743453
OpenAlexW2952810976

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.