ArticleAging2019
Anti-aging interventions affect lifespan variability in sex, strain, diet and drug dependent fashion.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Short lifespan is one's fate, long lifespan is one's achievement: lessons from Daphnia.GeroScience · 2024Article
- Attitudes towards geroprotection: measuring willingness, from lifestyle changes to drug use.Frontiers in aging · 2024Article
- Estimating Genetic Variance in Life-Span Response to Diet: Insights From Statistical Simulation.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Aging and short-term calorie restriction differently affect the cardiac and skeletal muscle expression of genes regulating energy substrate utilization in male rats.Biogerontology · 2022Article
- Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes.Mechanisms of ageing and development · 2022Article
- Theaflavin-regulated Imd condensates controliScience · 2021Article
- Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.Journal of translational genetics and genomics · 2021Article
- Global associations between macronutrient supply and age-specific mortality.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.Aging cell · 2020Article
- The road ahead for health and lifespan interventions.Ageing research reviews · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
It was recently reported that socio-economic factors related differences in human life expectancy are associated with differences in the variance of age at death. To determine whether anti-aging interventions also alter the variance of longevity, we have analyzed data from mice subjected to treatment with drugs that affect aging or to calorie restriction and from long-lived mutant mice. The relationship of changes in longevity and in longevity variance was found to depend on sex and treatment and apparently also on strain. Increased longevity of male mice treated with effective anti-aging drugs was accompanied by reduced variance of age at death and apparent reduction of early life mortality. Life extension induced by growth-hormone related mutations and calorie restriction tended to increase longevity variance in females only. We conclude that impact of anti-aging interventions on the variance of age at death and distribution of individual lifespans in laboratory mice is treatment-dependent and sexually dimorphic.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.