Evidence map›Paper›PMID 31239283›Full record

ArticleThe Journal of cell biology2019

A tensile trilayered cytoskeletal endotube drives capillary-like lumenogenesis.

Liakot A Khan, Gholamali Jafari, Nan Zhang, Edward Membreno, Siyang Yan, Hongjie Zhang, Verena Gobel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Epithelial morphogenesis, tubulogenesis and forces in organogenesis.Current topics in developmental biology · 2021
    Review
  3. Article
  4. A Series of Tubes: TheJournal of developmental biology · 2020
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 3 countries.

Liakot A KhanMucosal Immunology and Biology Research Center, Developmental Biology and Genetics Core, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA.ORCID 0000-0003-3507-4301
Gholamali JafariMucosal Immunology and Biology Research Center, Developmental Biology and Genetics Core, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA.
Nan ZhangMucosal Immunology and Biology Research Center, Developmental Biology and Genetics Core, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA.
Edward MembrenoMucosal Immunology and Biology Research Center, Developmental Biology and Genetics Core, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA.
Siyang YanMucosal Immunology and Biology Research Center, Developmental Biology and Genetics Core, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA.
Hongjie ZhangMucosal Immunology and Biology Research Center, Developmental Biology and Genetics Core, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA.
Verena GobelMucosal Immunology and Biology Research Center, Developmental Biology and Genetics Core, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA vgobel@mgh.harvard.edu.ORCID 0000-0003-2641-4466
Harvard University · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2000 to 2019
$31.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
ApicalMembrane Modeling in TubulogenesisR01GM078653 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI GOBEL, VERENA · 2006 to 2017
$2.9M
A Zeiss LSM800 confocal microscope with AiryscanS10OD021577 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2016 to 2016
$374k
NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIGMS NIH HHS R01 GM078653NIH HHS P40 OD010440NIH HHS S10 OD021577
6 · The paper itself

Abstract

Unicellular tubes are components of internal organs and capillaries. It is unclear how they meet the architectural challenge to extend a centered intracellular lumen of uniform diameter. In an RNAi-based

Indexed as

ActinsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCapillariesCytoskeletal ProteinsCytoskeletonIntermediate Filament ProteinsIntermediate FilamentsMorphogenesisRNA InterferenceTubulinACT-5 protein, C elegansActinsCaenorhabditis elegans ProteinsCytoskeletal ProteinsERM-1 protein, C elegansIFA-4 protein, C elegansIFB-1 protein, C elegansIFC-2 protein, C elegansIntermediate Filament ProteinsTubulin

Identifiers

PMID31239283
PMCPMC6605810
OpenAlexW2955992632

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.