Evidence map›Paper›PMID 31239384›Full record

ArticlemBio2019

The Human Cytomegalovirus Chemokine vCXCL-1 Modulates Normal Dissemination Kinetics of Murine Cytomegalovirus

Joseph W Jackson, Trevor J Hancock, Ellen LaPrade, Pranay Dogra, Eric R Gann, Thomas J Masi, Ravichandran Panchanathan, William E Miller, Steven W Wilhelm, Tim E Sparer

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Joseph W JacksonDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Trevor J HancockDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Ellen LaPradeDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Pranay DograDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0003-2031-9855
Eric R GannDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Thomas J MasiDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Ravichandran PanchanathanDepartment of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
William E MillerDepartment of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0001-6900-4884
Steven W WilhelmDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0001-6283-8077
Tim E SparerDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA tsparer@utk.edu.ORCID 0000-0002-5543-6691
University of Tennessee at Knoxville · USUniversity of Cincinnati Medical Center · USUniversity of Tennessee Medical Center · US

Funding

Mechanisms of vGPCR mediated Cytomegalovirus Growth in the Salivary GlandR01AI121028 · NIAID · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 2018 to 2021
$1.4M
Development of salisphere-derived systems for the study of cytomegalovirus vGPCR directed viral growth in the salivary glandR21DE026267 · NIDCR · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 2017 to 2018
$452k
Novel Cytomegalovirus' Chemokines Contribute to Innate Immune Cell Viral DisseminationR15AI144683 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI SPARER, TIMOTHY E · 2019 to 2019
$430k
NIAID NIH HHS R01 AI121028NIAID NIH HHS R15 AI144683NIDCR NIH HHS R21 DE026267
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a betaherpesvirus that is a significant pathogen within newborn and immunocompromised populations. Morbidity associated with HCMV infection is the consequence of viral dissemination. HCMV has evolved to manipulate the host immune system to enhance viral dissemination and ensure long-term survival within the host. The immunomodulatory protein vCXCL-1, a viral chemokine functioning primarily through the CXCR2 chemokine receptor, is hypothesized to attract CXCR2

Indexed as

AnimalsChemokine CXCL1CytomegalovirusCytomegalovirus InfectionsHost-Pathogen InteractionsHumansKineticsMiceMice, Inbred BALB CMuromegalovirusNeutrophilsReceptors, Interleukin-8BVirulence FactorsVirus ReplicationChemokine CXCL1CXCL1 protein, humanReceptors, Interleukin-8BVirulence FactorsbetaherpesviruscytomegalovirusMCMVneutrophilsvCXCL-1viral chemokines

Identifiers

PMID31239384
PMCPMC6593410
OpenAlexW2956138021

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.