SynthesisJournal of general internal medicine2019
The Association Between Polypharmacy and Physical Function in Older Adults: a Systematic Review.
Synthesis in Journal of general internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 87 citations in OpenAlex.
- Exercise reduces the risk of falls in women with polypharmacy: secondary analysis of a randomized controlled trial.Scientific reports · 2025Trial
- Effect of polypharmacy and potentially inappropriate medications on physical functional decline among older adults with advanced cancer receiving systemic treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Trial
- Trial
- Metformin Partially Attenuates Simvastatin-Induced Myotoxic Responses in C2C12 Myotubes Through Metabolic Adaptation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Optimizing polypharmacy management in older adults: impact of an interdisciplinary outpatient clinic on long-term function and quality of life.European geriatric medicine · 2026Observational
- Drug Burden Index and Its Association With Functional Outcomes in Patients Receiving Hemodialysis.Kidney medicine · 2026Article
- Prevalence and impact of prescribing cascades in community-dwelling adults: Longitudinal analysis of the Irish longitudinal study on ageing (TILDA).British journal of clinical pharmacology · 2026Article
- Deprescribing: Reducing Harm, Enhancing Care.Rambam Maimonides medical journal · 2026Review
- Physical activity and its associated factors in frail geriatric patients: a cross-sectional study utilizing the COM-B model.BMC geriatrics · 2026Article
- Association Between Polypharmacy and Physical Function in Middle-aged Adults: Findings from the CARDIA Function Study.Journal of general internal medicine · 2026Article
- Medication Reduction is Associated with Improved Activities of Daily Living and Muscle Strength in Post-Stroke Patients with Polypharmacy.JMA journal · 2026Article
- Association of blood-activating commercial Chinese polyherbal preparation with clinical outcomes in older patients with ischemic cardiovascular or cerebrovascular diseases: a real-world cohort study.Frontiers in pharmacology · 2026Article
- Trends in drug-drug interaction prevalence and longitudinal associations with health outcomes in the older community-dwelling population: Findings from The Irish LongituDinal study on Ageing.British journal of clinical pharmacology · 2025Article
- Article
- Foot Muscle Cross-Sectional Area and Recurrent Falls: A Preliminary MRI-Based Evaluation.Cureus · 2025Article
- Impact of resistance and high-intensity interval training on body composition, physical function, and temporal dynamics of adaptation in older women with impaired cardiometabolic health: a randomized clinical trial.BMC sports science, medicine & rehabilitation · 2025Article
- Analysis of drug patterns and drug-drug-interactions: associations with physical performance in middle-aged military personnel undergoing rehabilitation- a retrospective cohort study.Journal of pharmaceutical health care and sciences · 2025Article
- Commonly prescribed multi-medication therapies exert sex-specific effects on Alzheimer's disease pathology and metabolomic profiles in AppAlzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Polypharmacy Prevalence Among Older Adults Based on the Survey of Health, Ageing and Retirement in Europe: An Update.Journal of clinical medicine · 2025Article
- Identifying what matters to adults with mobility limitations regarding their experiences with medications: A concept mapping study.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReduced physical function and polypharmacy (PPha) are two highly prevalent negative effects of aging, which are expected to increase more, since demographic aging is expected to grow rapidly within the next decades. Previous research suggests that polypharmacy (PPha) is a predictor of poor physical function and vice versa in older adults and therefore we conducted a systematic review of the literature to summarize and critically analyze the relationship between physical function and PPha and vice versa in older adults, in order to provide recent scientific evidence.
methodsWe searched MEDLINE and Embase from their inception to 19th October 2018 for English-language observational studies or trials assessing the effect of PPha on physical function and vice versa in older adults. Two investigators independently extracted study data and assessed the quality of the studies, after having screened the available studies from the literature search. Any disagreement was resolved by consensus.
resultsEighteen observational studies met the inclusion criteria. Eight studies assessed the impact of physical function on PPha and ten studies assessed the impact of PPha on physical function. Regarding the studies with PPha measurements as the outcome, all of them, except for one, found that better physical function is associated with lower risk of PPha. Likewise, all the studies with physical function measurements as the outcome, except for one, suggested that PPha is associated with lower physical function. DISCUSSION: Evidence examining the effect of PPha on physical function and vice versa in older adults suggests a strong bidirectional association between these two factors and clinicians should be aware of this strong relationship. The limitations of our study include the high variability in PPha definitions and physical function measures, and the treatment of PPha and physical function as constant instead of time-varying variables in the studies' analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.