Evidence map›Paper›PMID 31243130›Full record

ArticleJournal of virology2019

Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors.

Adriaan H de Wilde, A Linda Boomaars-van der Zanden, Anja W M de Jong, Montserrat Bárcena, Eric J Snijder, Clara C Posthuma

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Classification, replication, and transcription ofFrontiers in microbiology · 2023
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Adriaan H de WildeMolecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
A Linda Boomaars-van der ZandenMolecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Anja W M de JongSection Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Montserrat BárcenaSection Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-7719-4443
Eric J Snijder *Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands e.j.snijder@lumc.nl.ORCID 0000-0003-3297-2309
Clara C Posthuma *Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-4839-2077
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, the cyclophilin inhibitors cyclosporine (CsA) and alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the order

Indexed as

ArterivirusCell LineCyclophilinsCyclosporineEquartevirusHEK293 CellsHumansMutationNidoviralesNucleic Acid Synthesis InhibitorsRNA-Dependent RNA PolymeraseRNA, ViralViral Nonstructural ProteinsVirus ReplicationCyclophilinsCyclosporineNucleic Acid Synthesis InhibitorsRNA-Dependent RNA PolymeraseRNA, ViralViral Nonstructural Proteinsalisporivirarteriviruscyclosporinedrug resistancehost factorsnidovirusnonstructural proteinsreplication

Identifiers

PMID31243130
PMCPMC6714810
OpenAlexW2954121006

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.