ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019
Diffusion tensor imaging reveals abnormal brain networks in elderly subjects with subjective cognitive deficits.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Brain Topological Changes in Subjective Cognitive Decline and Associations with Amyloid Stages.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Heterogeneous brain abnormalities in subjective cognitive decline converge on a common network and their transcriptional signature.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Multimodal MRI reveals distinct hippocampal subregional alterations inFrontiers in aging neuroscience · 2025Article
- Research progress on brain network imaging biomarkers of subjective cognitive decline.Frontiers in neuroscience · 2025Review
- Machine learning analysis reveals aberrant dynamic changes in amplitude of low-frequency fluctuations among patients with retinal detachment.Frontiers in neuroscience · 2023Article
- Characterization of the angular gyrus in an older adult population: a multimodal multilevel approach.Brain structure & function · 2023Article
- Characterization of diffusion magnetic resonance imaging revealing relationships between white matter disconnection and behavioral disturbances in mild cognitive impairment: a systematic review.Frontiers in neuroscience · 2023Review
- Markov model combined with MR diffusion tensor imaging for predicting the onset of Alzheimer's disease.Open life sciences · 2023Article
- Shared and specific dynamics of brain activity and connectivity in amnestic and nonamnestic mild cognitive impairment.CNS neuroscience & therapeutics · 2022Article
- Dementia Risk Factors Modify Hubs but Leave Other Connectivity Measures Unchanged in Asymptomatic Individuals: A Graph Theoretical Analysis.Brain connectivity · 2022Article
- Identification of cholinergic centro-cingulate topography as main contributor to cognitive functioning in Parkinson's disease: Results from a data-driven approach.Frontiers in aging neuroscience · 2022Article
- Decreased Resting-State Functional Complexity in Elderly with Subjective Cognitive Decline.Entropy (Basel, Switzerland) · 2021Article
- The impact of white matter hyperintensities on speech perception.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Structural and Functional Hippocampal Changes in Subjective Cognitive Decline From the Community.Frontiers in aging neuroscience · 2020Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeSome elders with subjective cognitive deficits (SCD) develop prodromal phase of dementia over time; however, little is known about how they differ from those with normal cognition (NC). Thus, we aim to distinguish the differences in the brain network of elders with SCD and NC.
methodsMultiple diffusion-weighted images (DWI) and T1-weighted images were obtained from 18 subjects with NC and 26 subjects with SCD. Using network-based statistics (NBS) analysis, we extracted abnormal brain subnetworks and localized abnormal brain connectivity. We also ran correlation analysis to compare the affected regions and the results of the neurocognitive assessments.
resultsAltered subnetworks were found in the superior parietal gyrus, angular gyrus, precuneus, posterior cingulum, putamen, precentral gyrus, postcentral gyrus, and paracentral lobule. They were also associated with scores on the word list recall, word list recognition, and Boston naming test.
conclusionsElders with SCD had distinctive brain network alterations when compared with those of elders with NC. The results are also in line with the previously identified characteristics of mild cognitive impairment (MCI) and of Alzheimer's disease (AD) in a milder form. We speculate that it may be possible to predict AD progression early in the SCD stage using NBS analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.