Evidence map›Paper›PMID 31245376›Full record

ReviewFrontiers in nutrition2019

Weight Gain During Treatment of Bipolar Disorder (BD)-Facts and Therapeutic Options.

Harald Mangge, Susanne Bengesser, Nina Dalkner, Armin Birner, Frederike Fellendorf, Martina Platzer, Robert Queissner, Rene Pilz, Alexander Maget, Bernd Reininghaus and 6 more

Abstract readReview
In one paragraph

Review in Frontiers in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Mechanisms of weight gain associated with valproic acid: a scoping review.European archives of psychiatry and clinical neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
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  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Harald ManggeClinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria.
Susanne BengesserDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Nina DalknerDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Armin BirnerDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Frederike FellendorfDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Martina PlatzerDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Robert QueissnerDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Rene PilzDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Alexander MagetDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Bernd ReininghausDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Carlo HammDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Konstantin BauerDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Alexandra RiegerDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Sieglinde ZelzerClinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria.
Dietmar FuchsDivision of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Eva ReininghausDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bipolar disorder (BPD) is a mood disorder, which is characterized by alternating affective states, namely (hypo)mania, depression, and euthymia. Evidence is growing that BPD has indeed a biologic substrate characterized by chronic inflammation, oxidative stress, and disturbed energy metabolism. Apart from this, there is obviously a hereditary component of this disease with multi-genetic factors. Most probably a susceptibility threshold favors the outbreak of clinical disease after a cascade of stress events that remain to be elucidated in more detail. Evidence is also growing that weak points in brain energy metabolism contribute to outbreak and severity of BPD. Conventional psychopharmacologic therapy must be reassessed under the aspects of weight cycling and development of central obesity as a deterioration factor for a worse clinical course leading to early cardiovascular events in BPD subgroups.

Indexed as

biochemistrybipolar disorderinflammationobesityoxidative stressweight gain

Identifiers

PMID31245376
PMCPMC6579840

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.