Evidence map›Paper›PMID 31258334›Full record

ArticleJournal of experimental neuroscience2019

What Is Excitation/Inhibition and How Is It Regulated? A Case of the Elephant and the Wisemen.

Hai-Yan He, Hollis T Cline

Open access · goldAbstract readComment
In one paragraph

Article in Journal of experimental neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Network Activity Shapes Inhibitory Synaptic Development in the Mouse Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Disentangling metabolic and neurovascular timescales supporting cognitive processes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Impact of aging on the GABAbioRxiv : the preprint server for biology · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hai-Yan HeThe Scripps Research Institute, La Jolla, CA, USA.
Hollis T ClineThe Scripps Research Institute, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-4887-9603
Scripps Research Institute · US

Funding

Activity-dependent Development of Visual System DevelopmentR01EY011261 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 1996 to 2018
$11.1M
Development of midbrain circuitryR01EY027437 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 2018 to 2020
$1.9M
NEI NIH HHS R01 EY011261NEI NIH HHS R01 EY027437
6 · The paper itself

Abstract

The balance between excitation and inhibition in neuronal circuits has drawn more and more attention in recent years, due to its proposed multifaceted functions in the normal neural circuit as well as its potential roles in the etiology of many neurological disorders. Here, we discuss the importance of clearly defining excitation/inhibition by experimental measurements and the implications of some recent studies to our understanding of the regulation of excitation/inhibition at the neuronal level.

Indexed as

circuit dysfunctionExcitation/inhibition balanceintrinsic excitabilitysensory-evoked synaptic currentspontaneous synaptic current

Identifiers

PMID31258334
PMCPMC6591655
OpenAlexW2954966372

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.