ArticleJournal of clinical medicine2019
Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Prospective Association Between Weight Variability and Subsequent Long-Term Weight Loss in the CALERIE Study.Obesity (Silver Spring, Md.) · 2026Trial
- Impact of Body Mass Index Variability on Kidney Disease Progression in a Large Type 1 Diabetes Cohort.Diabetes/metabolism research and reviews · 2026Article
- Long-term body mass index variability and the risk of cardiometabolic multimorbidity in middle-aged and older adults: Insights from two prospective cohorts.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Impact of Change, Fluctuation, or Variability in Weight on the Risk of Nonalcoholic Fatty Liver Disease in General Population: A Systematic Review and Meta-Analysis.Health science reports · 2025Article
- Review
- Impact of adiposity indices changes across the lifespan on risk of diabetes in women: trajectory modeling approach.BMC public health · 2024Article
- Association of midlife body-weight variability and cycles with earlier dementia onset: a nationwide cohort study.Alzheimer's research & therapy · 2024Article
- Weight Gain After Antiretroviral Therapy Initiation and Subsequent Risk of Metabolic and Cardiovascular Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Weight variability, physical functioning and incident disability in older adults.Journal of cachexia, sarcopenia and muscle · 2023Article
- Factors Affecting High Body Weight Variability.Journal of obesity & metabolic syndrome · 2023Article
- Outcomes for binge eating disorder in a remote weight-inclusive treatment program: a case report.Journal of eating disorders · 2023Article
- Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database.Endocrinology and metabolism (Seoul, Korea) · 2023Review
- Higher metabolic variability increases the risk of depressive disorder in type 2 diabetes mellitus: a longitudinal nationwide cohort study.Frontiers in psychiatry · 2023Article
- No Association between Vitamin D and Weight Gain: A Prospective, Population-Based Study.Nutrients · 2022Article
- Ramadan fasting and weight change trajectories: Time-varying association of weight during and after Ramadan in low-income and refugee populations.PLOS global public health · 2022Article
- Smoking Cessation, Weight Gain, and Risk for Type 2 Diabetes: A Prospective Study.International journal of public health · 2022Article
- Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease.Nutrients · 2021Article
- Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study).Preventive medicine reports · 2021Article
- Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease.Scientific reports · 2021Article
- Association between variability in body mass index and development of type 2 diabetes: Panasonic cohort study.BMJ open diabetes research & care · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to investigate how body weight fluctuation affects the risk of developing type 2 diabetes by conducting a nationwide cohort study. A total of 3,855,884 participants from the National Health Insurance System health check-up data from 2012 were included in this study, and follow-up continued until 2016. Body weight was measured at least thrice between 2009 and 2012. Body weight variability (BWV) was estimated using average successive variability (ASV) indices. Cox proportional hazards regression models were used to evaluate the association of BWV with the risk of type 2 diabetes using hazard ratios (HRs) and 95% confidence intervals (CIs). Body weight fluctuation was associated with a higher risk of incident diabetes after adjustment for confounders (HR 1.10, 95% CI 1.07, 1.12 in the highest BWV quartile compared to the lowest). Regardless of the weight change status, the highest ASV quartile of BWV increased the risk for diabetes. Even subjects with a normal glucose tolerance status and those aged under 65 years had a higher risk of diabetes if their body weight highly fluctuated during the follow-up years. Our results suggest that body weight variability is an independent risk factor for diabetes. It is important to pay attention to frequent body weight fluctuations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.