Evidence map›Paper›PMID 31265995›Full record

ReviewReproduction (Cambridge, England)2019

WOMEN IN REPRODUCTIVE SCIENCE: To be or not to be a testis.

Blanche Capel

Open access · bronzeAbstract readBiographyHistorical ArticleReview
In one paragraph

Review in Reproduction (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 39 citations in OpenAlex.

  1. Ovarian-Specific FOXL2 Protein Expression in Testes from Patients with Complete Androgen Insensitivity Syndrome and Undescended Testes.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2026
    Article
  2. How relevant is the mouse model for understanding human sex determination?International journal of biological sciences · 2025
    Article
  3. Article
  4. Article
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  6. Review
  7. Review
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  9. Analysis of XXAnimals : an open access journal from MDPI · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Blanche CapelDepartment of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.
Duke University Hospital · US

Funding

OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATIONR01HD039963 · NICHD · DUKE UNIVERSITY · PI CAPEL, BLANCHE · 2001 to 2025
$4.7M
Opposing Pathways in Mammalian Sex DeterminationR37HD039963 · NICHD · DUKE UNIVERSITY · PI CAPEL, BLANCHE · 2011 to 2020
$3.5M
NICHD NIH HHS R01 HD039963NICHD NIH HHS R37 HD039963
6 · The paper itself

Abstract

Work that established the testis as the driver of male development, and the Y chromosome as the bearer of the male-determining gene, established a working model, and set the stage for the molecular age of mammalian sex determination. The discovery and characterization of Sry/SRY at the top of the hierarchy in mammals launched the field in two major directions. The first was to identify the downstream transcription factors and other molecular players that drive the bifurcation of Sertoli and granulosa cell differentiation. The second major direction was to understand organogenesis of the early bipotential gonad, and how divergence of its two distinct morphogenetic pathways (testis and ovary) is regulated at the cellular level. This review will summarize the early discoveries soon after Sry was identified and focus on my study of the gonad as a model of organogenesis.

Indexed as

Cell DifferentiationOrganogenesisReproductionAnimalsBiomedical ResearchFemaleHistory, 20th CenturyHistory, 21st CenturyHumansMaleMiceOvaryTestisUnited StatesY Chromosome

Identifiers

PMID31265995
PMCPMC9945370
OpenAlexW2953522236

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.