Evidence map›Paper›PMID 31270446›Full record

ReviewNature nanotechnology2019

An atlas of nano-enabled neural interfaces.

Héctor Acarón Ledesma, Xiaojian Li, João L Carvalho-de-Souza, Wei Wei, Francisco Bezanilla, Bozhi Tian

Abstract readReview
In one paragraph

Review in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Ethical Precision in Nanoscale Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Mechanically adaptive and deployable intracortical probes enable long-term neural electrophysiological recordings.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Héctor Acarón LedesmaGraduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, USA.
Xiaojian LiBrain Cognition and Brain Disease Institute of Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People's Republic of China.
João L Carvalho-de-SouzaDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-3231-0436
Wei WeiDepartment of Neurobiology, University of Chicago, Chicago, IL, USA.
Francisco BezanillaInstitute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
Bozhi TianInstitute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA. btian@uchicago.edu.ORCID http://orcid.org/0000-0003-0593-0023

Funding

The Electrophysiological Studies of Voltage Gated ChannelsR01GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1985 to 2025
$9.1M
Graduate Program in Biophysical Sciences at the University of Chicago - Renewal 0T32EB009412 · NIBIB · UNIVERSITY OF CHICAGO · PI ENGEL, GREGORY S, SOSNICK, TOBIN R · 2009 to 2023
$4.9M
Circuit mechanisms for encoding naturalistic motion in the mammalian retinaR01NS109990 · NINDS · UNIVERSITY OF CHICAGO · PI WEI, WEI · 2018 to 2022
$3.3M
Silicon-based Injectable Micro-gels for Non-genetic and Wireless Modulation of Neurons, Cardiomyocytes and Neuromuscular SystemDP2NS101488 · NINDS · UNIVERSITY OF CHICAGO · PI TIAN, BOZHI · 2016 to 2016
$2.4M
Synaptic basis of motion detection in the retinaR01EY024016 · NEI · UNIVERSITY OF CHICAGO · PI WEI, WEI · 2014 to 2018
$1.9M
Cell-targeted Gold Nanoparticles for Photo-excitation fo Retinal Ganglion CellsR21EY027101 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BEZANILLA, FRANCISCO J · 2017 to 2018
$438k
Mechanisms underlying orientation selectivity in the mature mouse retinaF31EY029156 · NEI · UNIVERSITY OF CHICAGO · PI ACARON, HECTOR · 2019 to 2020
$78k
NEI NIH HHS F31 EY029156NEI NIH HHS R01 EY024016NEI NIH HHS R21 EY027101NIBIB NIH HHS T32 EB009412NIGMS NIH HHS R01 GM030376NINDS NIH HHS DP2 NS101488NINDS NIH HHS R01 NS109990
6 · The paper itself

Abstract

Advances in microscopy and molecular strategies have allowed researchers to gain insight into the intricate organization of the mammalian brain and the roles that neurons play in processing information. Despite vast progress, therapeutic strategies for neurological disorders remain limited, owing to a lack of biomaterials for sensing and modulating neuronal signalling in vivo. Therefore, there is a pressing need for developing material-based tools that can form seamless biointerfaces and interrogate the brain with unprecedented resolution. In this Review, we discuss important considerations in material design and implementation, highlight recent breakthroughs in neural sensing and modulation, and propose future directions in neurotechnology research. Our goal is to create an atlas for nano-enabled neural interfaces and to demonstrate how emerging nanotechnologies can interrogate neural systems spanning multiple biological length scales.

Indexed as

AnimalsBiocompatible MaterialsBrainEquipment DesignHumansNanostructuresNanotechnologyNeuronsBiocompatible Materials

Identifiers

PMID31270446
PMCPMC6800006

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.