ArticleInternational journal of epidemiology2020
Associations of perinatal characteristics with endometriosis: a nationwide birth cohort study.
Article in International journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Measures of fetal growth and preterm birth and risk of endometriosis and adenomyosis in adult life: a systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2023Pooled it
- Risk of congenital anomalies among infants of patients with endometriosis: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Patients' knowledge, attitudes, and practices concerning endometriosis and its long-term management.BMC women's health · 2025Article
- Adverse childhood experiences and the risk of endometriosis-a nationwide cohort study.Human reproduction (Oxford, England) · 2025Article
- Increasing incidence and spatial hotspots of hospitalized endometriosis in France from 2011 to 2017.Scientific reports · 2022Article
- The Causal Evidence of Birth Weight and Female-Related Traits and Diseases: A Two-Sample Mendelian Randomization Analysis.Frontiers in genetics · 2022Article
- Association of Maternal Inflammation During Pregnancy With Birth Outcomes and Infant Growth Among Women With or Without HIV in India.JAMA network open · 2021Article
- The Predictability of Frailty Associated with Musculoskeletal Deficits: A Longitudinal Study.Calcified tissue international · 2021Article
- Educational note: addressing special cases of bias that frequently occur in perinatal epidemiology.International journal of epidemiology · 2021Article
- Environmental risk factors for endometriosis: A critical evaluation of studies and recommendations from the epidemiologic perspective.Current epidemiology reports · 2020Article
- Risk Factors for Endometriosis Among Egyptian Infertile Women with Different Disease Stages.SAGE open nursingArticle
- Are the Previously Reported Risk Factors for Endometriosis Actually Associated With Pain and Infertility Rather Than Endometriosis Itself?Reproductive medicine and biologyReview
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerinatal characteristics are associated with subsequent risk of several chronic diseases. Previous studies regarding endometriosis were based on small samples and retrospective data and were limited by unmeasured confounding bias, leading to conflicting and inconclusive findings. We investigated the associations of maternal and birth characteristics with risk of endometriosis among Swedish women of reproductive age.
methodsThis total-population register-based cohort study consisted of 628 312 singleton women born in Sweden between 1973 and 1987, who were followed for diagnosed endometriosis from age 15 years until the end of 2012. Multivariable Cox regression was applied to examine associations with perinatal characteristics. Residual unmeasured confounding was assessed through within-family and E-value analyses.
resultsDuring follow-up, 8262 women received an endometriosis diagnosis. There were clear dose-response/linear associations of endometriosis with lower maternal education, endometriosis in the mother [adjusted hazard ratio (aHR): 2.24, 95% confidence interval (CI): 2.04-2.46], maternal smoking during pregnancy (aHR: 1.18, 95% CI: 1.04-1.33 for moderate smoker and aHR: 1.36, 95% CI: 1.18-1.57 for heavy smoker vs non-smoker), lower birthweight, and lower birthweight-for-gestational age (aHR: 0.93 per standard deviation increase, 95% CI: 0.91-0.95). Within-family and E-value analyses suggested that these perinatal characteristics are robust predictors of the incidence of endometriosis. We also found that an estimated 26% of the association between maternal smoking and early-onset endometriosis could be explained by birthweight-for-gestational age.
conclusionThis study finds support for fetal origins of endometriosis, in that exposure to adverse environment or restricted development during the perinatal period may increase the risk. Further research is needed to provide an understanding of the underlying mechanisms.
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