Evidence map›Paper›PMID 31270713›Full record

ArticlePurinergic signalling2019

Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2Y

Nicole Brockmann, Parichat Sureechatchaiyan, David Müller, Tatiana Hennicke, Ralf Hausmann, Gerhard Fritz, Alexandra Hamacher, Matthias U Kassack

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nicole BrockmannInstitute of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Biochemistry, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Parichat SureechatchaiyanInstitute of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Biochemistry, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
David MüllerInstitute of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Biochemistry, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Tatiana HennickeInstitute of Toxicology, Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany.
Ralf HausmannMolecular Pharmacology, Rheinisch-Westfaelische Technische Hochschule Aachen, RWTH Aachen University, Aachen, Germany.
Gerhard FritzInstitute of Toxicology, Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany.
Alexandra HamacherInstitute of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Biochemistry, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
Matthias U KassackInstitute of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Biochemistry, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany. matthias.kassack@hhu.de.ORCID 0000-0002-9094-8481
Heinrich Heine University Düsseldorf · DERWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular nucleotides mediate multiple physiological effects such as proliferation, differentiation, or induction of apoptosis through G protein-coupled P2Y receptors or P2X ion channels. Evaluation of the complete physiological role of nucleotides has long been hampered by a lack of potent and selective ligands for all P2 subtypes. Meanwhile, for most of the P2 receptors, selective ligands are available, but only a few potent and selective P2Y

Indexed as

Drug DiscoveryAnimalsHumansNaphthalenesPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y2SuraminNaphthalenesPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y2SuraminAntagonistCalcium assayP2Y2 receptorPurinergic receptorsSuramin

Identifiers

PMID31270713
PMCPMC6737154
OpenAlexW2954499455

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.