Evidence map›Paper›PMID 31271253›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2020

Nucleic-Acid Structures as Intracellular Probes for Live Cells.

Devleena Samanta, Sasha B Ebrahimi, Chad A Mirkin

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Proximity-Driven DNA Nanosensors.ECS sensors plus · 2023
    Article
  12. Article
  13. Review
  14. Functional Xeno Nucleic Acids for Biomedical Application.Chemical research in Chinese universities · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Devleena SamantaDepartment of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.ORCID https://orcid.org/0000-0002-0647-7673
Sasha B EbrahimiDepartment of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.ORCID https://orcid.org/0000-0003-2752-5109
Chad A MirkinDepartment of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.ORCID https://orcid.org/0000-0002-6634-7627

Funding

Project 3: Spherical Nucleic Acids as Immunotherapeutic Agents for Prostate CancerU54CA199091 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STEGH, ALEXANDER H. · 2015 to 2019
$11.7M
Enhancing HIV Research Training Capacity in University of Rwanda's Research OfficeG11TW010348 · FIC · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ADEDIMEJI, ADEBOLA, JANSEN, STEFAN · 2017 to 2019
$296k
Air Force Office of Scientific Research FA9550-17-1-0348Air Force Research Laboratory FA8650-15-2-5518Basic Research Office of the Assistant Secretary of Defense for Research and EngineeringNCI NIH HHS U54 CA199091NIH HHS U54CA199091Office of Naval Research N00014-15-1-0043Vannevar Bush Faculty Fellowship
6 · The paper itself

Abstract

The chemical composition of cells at the molecular level determines their growth, differentiation, structure, and function. Probing this composition is powerful because it provides invaluable insight into chemical processes inside cells and in certain cases allows disease diagnosis based on molecular profiles. However, many techniques analyze fixed cells or lysates of bulk populations, in which information about dynamics and cellular heterogeneity is lost. Recently, nucleic-acid-based probes have emerged as a promising platform for the detection of a wide variety of intracellular analytes in live cells with single-cell resolution. Recent advances in this field are described and common strategies for probe design, types of targets that can be identified, current limitations, and future directions are discussed.

Indexed as

AnimalsAptamers, NucleotideBiosensing TechniquesDNA, CatalyticHumansNucleic Acid ConformationNucleic Acid HybridizationNucleic Acid ProbesSingle-Cell AnalysisAptamers, NucleotideDNA, CatalyticNucleic Acid ProbesaptamersDNAzymehybridizationtheranostics

Identifiers

PMID31271253
PMCPMC6942251

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.