ArticleNeurology international2019
Testosterone levels in men with chronic migraine.
Article in Neurology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Giving Researchers a Headache - Sex and Gender Differences in Migraine.Frontiers in neurology · 2020Pooled it
- The Prevalence of Migraine With Anxiety Among Genders.Frontiers in neurology · 2020Pooled it
- Sex-specific considerations in migraine therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Headache in individuals undergoing hormone therapy for gender transition: A cross-sectional, observational study.Headache · 2026Observational
- Trends and age-period-cohort analysis of migraine incidence in China from 1990 to 2021.PloS one · 2026Article
- Neurology of Androgens and Androgenic Supplements.Current neurology and neuroscience reports · 2025Review
- The role and interaction of hypothalamic-related neurotransmitters in migraine.The journal of headache and pain · 2025Review
- Migraine with and without aura-two distinct entities? A narrative review.The journal of headache and pain · 2025Review
- Sex difference in TRPM3 channel functioning in nociceptive and vascular systems: an emerging target for migraine therapy in females?The journal of headache and pain · 2025Review
- The Global Burden of Migraine: A 30-Year Trend Review and Future Projections by Age, Sex, Country, and Region.Pain and therapy · 2025Article
- Migraine in men.The journal of headache and pain · 2025Review
- Sex hormone profiles in men with migraine: a cross-sectional, matched cohort study.Frontiers in neurology · 2025Article
- Sex differences in the clinical features of 2,841 patients with migraine: aFrontiers in neurology · 2025Article
- Headache disorders: a persistent public health challenge for the under 50s.Frontiers in neurology · 2024Article
- Considerations for hormonal therapy in migraine patients: a critical review of current practice.Expert review of neurotherapeutics · 2023Review
- Risk factors for migraine disease progression: a narrative review for a patient-centered approach.Journal of neurology · 2023Review
- Effect of testosterone therapy on migraine frequency and disability in two transgender patients: a case report.BMJ case reports · 2023Article
- Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine.Nature communications · 2022Article
- Sex and Gender Considerations in Episodic Migraine.Current pain and headache reports · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic migraine is a frequent and debilitating condition affecting 14% of the general population. This prospective observational pilot study investigated whether men with chronic migraine have lower than expected total serum testosterone levels. We identified 14 men ages 26-51 at our Institution who fulfilled the ICHD-3b criteria for chronic migraine and obtained serum total testosterone levels. The mean total testosterone level in our 14 patients was 322 ng/dL (range: 120-542 ng/dL) which is in the lower 5% of the reference range for our laboratory (300-1080 ng/dL). Men with chronic migraine had lower total testosterone levels compared to published agematched normative median values by a median difference of 62 ng/dL (P=0.0494). This finding suggests that hypothalamic regulation is altered in patients with chronic migraine. Further studies are warranted to determine whether testosterone supplementation in men with chronic migraine reduces the number of headaches or the associated symptoms of hypogonadism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.