Evidence map›Paper›PMID 31295366›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019

RANKL Inhibition in Fibrous Dysplasia of Bone: A Preclinical Study in a Mouse Model of the Human Disease.

Biagio Palmisano, Emanuela Spica, Cristina Remoli, Rossella Labella, Annamaria Di Filippo, Samantha Donsante, Fabiano Bini, Domenico Raimondo, Franco Marinozzi, Alan Boyde and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  10. Bone pain in fibrous dysplasia does not rely on aberrant sensory nerve sprouting or neuroma formation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
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  20. GsαBone research · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Biagio PalmisanoDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Emanuela SpicaDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Cristina RemoliDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Rossella LabellaDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Annamaria Di FilippoDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Samantha DonsanteDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Fabiano BiniDepartment of Mechanical and Aerospace Engineering, Sapienza University, Rome, Italy.
Domenico RaimondoDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Franco MarinozziDepartment of Mechanical and Aerospace Engineering, Sapienza University, Rome, Italy.
Alan BoydeDental Physical Sciences, Barts' and The London School of Medicine and Dentistry, Queen Mary University of London (QMUL), London, UK.
Pamela RobeySkeletal Biology Section, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA.
Alessandro CorsiDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Mara RiminucciDepartment of Molecular Medicine, Sapienza University, Rome, Italy.
Sapienza University of Rome · ITNational Institutes of Health · USQueen Mary University of London · GB

Funding

The role of stem cells in skeletal health and diseaseZIADE000380 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI ROBEY, PAMELA G · 2009 to 2025
$30.6M
Intramural NIH HHS ZIA DE000380
6 · The paper itself

Abstract

Fibrous dysplasia of bone/McCune-Albright syndrome (Polyostotic FD/MAS; OMIM#174800) is a crippling skeletal disease caused by gain-of-function mutations of G

Indexed as

AnimalsBiomechanical PhenomenaBone and BonesCalcification, PhysiologicDenosumabDisease Models, AnimalDisease ProgressionFibrous Dysplasia of BoneGTP-Binding Protein alpha Subunits, GsHumansMice, TransgenicOsteolysisPeptide Elongation Factor 1PhenotypeRANK LigandRatsDenosumabGTP-Binding Protein alpha Subunits, GsPeptide Elongation Factor 1RANK LigandBONE REMODELLINGDENOSUMABFIBROUS DYSPLASIAGSαRANKL

Identifiers

PMID31295366
PMCPMC8408916
OpenAlexW2956900515

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.