Evidence map›Paper›PMID 31300521›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Eugen V Khomula, Dioneia Araldi, Jon D Levine

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. The Nociceptor Primary Cilium Contributes to Mechanical Nociceptive Threshold and Inflammatory and Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Review
  7. Article
  8. Opioid-Induced Hyperalgesia and Tolerance Are Driven by HCN Ion Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  9. Article
  10. Multi-Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Opioid-Induced Pronociceptive Signaling in the Gastrointestinal Tract Is Mediated by Delta-Opioid Receptor Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  15. Article
  16. PI3Kγ/AKT Signaling in High Molecular Weight Hyaluronan (HMWH)-Induced Anti-Hyperalgesia and Reversal of Nociceptor Sensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  17. Article
  18. Opioid-Induced Hyperalgesic Priming in Single Nociceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  19. Article
  20. Mechanisms Mediating High-Molecular-Weight Hyaluronan-Induced Antihyperalgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Eugen V KhomulaDepartments of Medicine and Oral Surgery and Division of Neuroscience, University of California at San Francisco, San Francisco, California 94143.ORCID 0000-0003-0221-2237
Dioneia AraldiDepartments of Medicine and Oral Surgery and Division of Neuroscience, University of California at San Francisco, San Francisco, California 94143.ORCID 0000-0001-8379-2901
Jon D LevineDepartments of Medicine and Oral Surgery and Division of Neuroscience, University of California at San Francisco, San Francisco, California 94143 jon.levine@ucsf.edu.
University of California, San Francisco · US

Funding

Nociceptor mechanisms in the transition from acute to chronic painR01NS084545 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2014 to 2018
$3.1M
NINDS NIH HHS R01 NS084545
6 · The paper itself

Abstract

Opioid-induced hyperalgesia (OIH) is a serious adverse event produced by opioid analgesics. Lack of an

Indexed as

Neuronal PlasticityAction PotentialsAnalgesics, OpioidAnimalsCalcium SignalingFentanylGanglia, SpinalHyperalgesiaMaleNociceptorsRatsRats, Sprague-DawleyReceptors, OpioidAnalgesics, OpioidFentanylReceptors, Opioidcalciumexcitabilityfentanylhyperalgesic primingmu-opioid receptor (MOR)opioid-induced hyperalgesia (OIH)

Identifiers

PMID31300521
PMCPMC6733538
OpenAlexW2959524766

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.