Evidence map›Paper›PMID 31300538›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis.

Lianjie Miao, Jingjing Li, Jian Li, Yangyang Lu, David Shieh, Joseph E Mazurkiewicz, Margarida Barroso, John J Schwarz, Hong-Bo Xin, Harold A Singer and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

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  15. Heart organoids and tissue models for modeling development and disease.Seminars in cell & developmental biology · 2021
    Review
  16. Molecular and cellular basis of embryonic cardiac chamber maturation.Seminars in cell & developmental biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Lianjie MiaoDepartment of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208.ORCID 0000-0002-8286-9783
Jingjing LiDepartment of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208.
Jian LiKey Laboratory of Molecular Medicine, Ministry of Education, Fudan University, 200032 Shanghai, China.
Yangyang LuDepartment of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208.
David ShiehDepartment of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208.
Joseph E MazurkiewiczDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY 12208.
Margarida BarrosoDepartment of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208.ORCID 0000-0002-0407-3181
John J SchwarzDepartment of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208.
Hong-Bo XinInstitute of Translational Medicine, Nanchang University, 330031 Nanchang, China.
Harold A SingerDepartment of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208.
Peter A VincentDepartment of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208.
Weimin ZhongDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520.
Glenn L RadiceDepartment of Medicine, Division of Cardiology, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, RI 02903.
Leo Q WanDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180.ORCID 0000-0001-8371-5623
Zhen-Chuan FanState Key Laboratory for Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, 300457 Tianjin, China.
Guoying HuangKey Laboratory of Molecular Medicine, Ministry of Education, Fudan University, 200032 Shanghai, China.
Mingfu WuDepartment of Molecular and Cellular Physiology, Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208; wum@amc.edu.ORCID 0000-0003-0155-2328
Albany Medical Center Hospital · USFudan University · CNBrown University · USNanchang University · CNRensselaer Polytechnic Institute · USTianjin University of Science and Technology · CNYale University · US

Funding

CALCIUM/CALMODULIN ACTIVATED KINIASES IN SMOOTH MUSCLER01HL049426 · NHLBI · WEIS CENTER FOR RESEARCH-GEISINGER CLINC · PI SINGER, HAROLD A · 1994 to 2019
$6.2M
Signaling by beta 1 integrins regulates ventricular wall morphogenesis and compactionR01HL121700 · NHLBI · UNIVERSITY OF HOUSTON · PI Mingfu Wu, YANG Kevin XIANG · 2015 to 2026
$5.4M
Mechanotransduction in Heart Development and RegenerationR01HL138493 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI RADICE, GLENN LAWRENCE · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL049426NHLBI NIH HHS R01 HL121700NHLBI NIH HHS R01 HL138493
6 · The paper itself

Abstract

The roles of cellular orientation during trabecular and ventricular wall morphogenesis are unknown, and so are the underlying mechanisms that regulate cellular orientation. Myocardial-specific

Indexed as

OrganogenesisAnimalsCadherinsHeart VentriclesIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, KnockoutMyocytes, CardiacNerve Tissue ProteinsCadherinsCdh2 protein, mouseIntracellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsNumbl protein, mouseNumb protein, mousecellular orientationendocytosisNumb family proteinssingle-cell lineage tracingtrabecular morphogenesis

Identifiers

PMID31300538
PMCPMC6681736
OpenAlexW2967124660

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.