ArticleNature communications2019
Long-term imaging of dorsal root ganglia in awake behaving mice.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 67 citations in OpenAlex.
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- High-speed whole-brain imaging in Drosophila.Nature communications · 2026Article
- Metabolite-neuro-immune relay in chronic pain: spatial-temporal lactate, succinate and itaconate signalling as drivers of glial reprogramming and neuronal sensitisation.Frontiers in pharmacology · 2026Review
- Focal Adhesion Kinase Inhibition Ameliorates Burn Injury-Induced Chronic Pain in Rats.Molecular neurobiology · 2025Article
- Emergence of a brainstem somatosensory tonotopic map for substrate vibration.Nature neuroscience · 2025Article
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- Long-term optical imaging of the spinal cord in awake behaving mice.Nature methods · 2024Article
- Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models.EMBO reports · 2024Article
- In vivo imaging of vagal-induced myenteric plexus responses in gastrointestinal tract with an optical window.Nature communications · 2024Article
- Light-Inducible Activation of TrkA for Probing Chronic Pain in Mice.ACS chemical biology · 2024Article
- Commentary on "Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain".Neural regeneration research · 2024Article
- Review
- Toward a brighter constellation: multiorgan neuroimaging of neural and vascular dynamics in the spinal cord and brain.Neurophotonics · 2024Article
- The Afferent Function of Adipose Innervation.Diabetes · 2024Review
- Generalized modality responses in primary sensory neurons of awake mice during the development of neuropathic pain.Frontiers in neuroscience · 2024Article
- Perspective of Calcium Imaging Technology Applied to Acupuncture Research.Chinese journal of integrative medicine · 2024Review
- Towards a Brighter Constellation: Multi-Organ Neuroimaging of Neural and Vascular Dynamics in the Spinal Cord and Brain.bioRxiv : the preprint server for biology · 2023Article
- Article
- Piezo1-mediated spontaneous calcium transients in satellite glia impact dorsal root ganglia development.PLoS biology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The dorsal root ganglia (DRG) contain the somas of first-order sensory neurons critical for somatosensation. Due to technical difficulties, DRG neuronal activity in awake behaving animals remains unknown. Here, we develop a method for imaging DRG at cellular and subcellular resolution over weeks in awake mice. The method involves the installation of an intervertebral fusion mount to reduce spinal movement, and the implantation of a vertebral glass window without interfering animals' motor and sensory functions. In vivo two-photon calcium imaging shows that DRG neuronal activity is higher in awake than anesthetized animals. Immediately after plantar formalin injection, DRG neuronal activity increases substantially and this activity upsurge correlates with animals' phasic pain behavior. Repeated imaging of DRG over 5 weeks after formalin injection reveals persistent neuronal hyperactivity associated with ongoing pain. The method described here provides an important means for in vivo studies of DRG functions in sensory perception and disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.