Evidence map›Paper›PMID 31300983›Full record

ArticleMolecular and cellular biochemistry2019

Ameliorating effect of lipo-ATRA treatment on the expression of TIG3 and its suppressing effect on PPARγ gene expression in lung cancer animal model.

Ragavi Ravichandran, S Viswanathan, V M Berlin Grace, Lucia Bonati, Jini Narayanan

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ragavi RavichandranDepartment of Biotechnology, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, Tamilnadu, 641114, India.
S ViswanathanDepartment of Biotechnology, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, Tamilnadu, 641114, India.
V M Berlin GraceDepartment of Biotechnology, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, Tamilnadu, 641114, India. berlinbiochem@gmail.com.ORCID http://orcid.org/0000-0002-3569-1345
Lucia BonatiBiotechnology, ETH Zurich, Hebelstrasse, 17, 4056, Basel, Switzerland.
Jini NarayananDepartment of Biotechnology, Sugarcane Breeding Institute, Coimbatore, Tamil Nadu, 641007, India.
Karunya University · INETH Zurich · CHSugarcane Breeding Institute · IN

Funding

Department of Biotechnology (DBT) [BT/PR14632/NNT/28/824/2015Department of Science and Technology-Science and Engineering Research board (DST-SERB) SB/YS/LS-252/2013(May 15 2014)Karunya short term Research grant 2018-2019 KITS/KSG/56/2018
6 · The paper itself

Abstract

This study aimed to find out the molecular therapeutic effect of lipo-ATRA on tumour suppressor TIG3 and cell proliferative biomarker PPARγ in B (a) P-induced lung cancer model. In RT-PCR study, ATRA- and lipo-ATRA-treated mice samples showed relatively higher TIG3 expression and decreased PPARγ expression (Band density) than cancer control. Among treatments, lipo-ATRA showed vital effect than free ATRA by enhancing TIG3 and decreasing PPARγ. The qPCR results also showed significant (p ≤ 0.05) difference in both TIG3 and PPAR (RQ values of TIG3, lipo-ATRA 23.85 ± 1.29; free ATRA 10.43 ± 1.81 and for PPARγ, lipo-ATRA 4.707 ± 1.21; free ATRA 15.78 ± 2.34). From this, we conclude that liposomal ATRA formulation is most preferable for prolonged delivery of ATRA at targeted site to favour molecular action. It implies that the therapeutic effect of lipo-ATRA in lung cancer was exhibited by ameliorating the TIG3 expression and by suppressing the expression of PPARγ.

Indexed as

AnimalsDisease Models, AnimalGene Expression Regulation, NeoplasticLiposomesLung NeoplasmsMaleMicePPAR gammaReceptors, Retinoic AcidTretinoinTumor Suppressor ProteinsLiposomesPPAR gammaReceptors, Retinoic AcidTIG3 protein, mouseTretinoinTumor Suppressor ProteinsBenzo (a) pyreneLipo-ATRALung cancerPPARγTIG3

Identifiers

PMID31300983
OpenAlexW2961990090

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.