ArticleJACC. Basic to translational science2019
Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.
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Article in JACC. Basic to translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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55citing papers in PubMed, 1 pooled it
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Extracellular Matrix Remodeling during Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2020Pooled it
- Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: etiology and sex-dependent differences.American journal of physiology. Heart and circulatory physiology · 2026Article
- The role of Western diet and gut microbiota in the pathogenesis of cardiovascular diseases.Frontiers in microbiology · 2026Review
- What Is Cardiometabolic HFpEF and How Can We Study it Preclinically?JACC. Basic to translational science · 2025Review
- HeterozygousJournal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine.Basic research in cardiology · 2025Article
- Sexual dimorphism in animal models of heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Cardiovascular, Kidney, Liver, and Metabolic Interactions in Heart Failure: Breaking Down Silos.Circulation research · 2025Review
- The Interplay of Heart Failure and Lung Disease: Clinical Correlations, Mechanisms, and Therapeutic Implications.Journal of respiratory biology and translational medicine · 2024Article
- Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure.American journal of physiology. Heart and circulatory physiology · 2024Review
- Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024Article
- Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction.Circulation research · 2024Article
- The pig as an optimal animal model for cardiovascular research.Lab animal · 2024Review
- Chronic kidney disease and left ventricular diastolic dysfunction (CKD-LVDD) alter cardiac expression of mitochondria-related genes in swine.Translational research : the journal of laboratory and clinical medicine · 2024Article
- Differences in vasomotor function of mesenteric arteries between Ossabaw minipigs with predisposition to metabolic syndrome and Göttingen minipigs.American journal of physiology. Heart and circulatory physiology · 2024Article
- Large animal models to study effectiveness of therapy devices in the treatment of heart failure with preserved ejection fraction (HFpEF).Heart failure reviews · 2024Review
- Characterization of a robust mouse model of heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2023Article
- The Role of the Vasculature in Heart Failure.Current heart failure reports · 2023Review
- Impact of sex and diet-induced weight loss on vascular insulin sensitivity in type 2 diabetes.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Synthetic growth hormone-releasing hormone agonist ameliorates the myocardial pathophysiology characteristic of heart failure with preserved ejection fraction.Cardiovascular research · 2023Article
Corrections and comments
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Authors and funding
23 authors.
T Dylan OlverDepartment of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri.
Jenna C EdwardsDepartment of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri.
Thomas J JurrissenDepartment of Nutrition and Exercise Physiology, University of Missouri-Columbia, Columbia, Missouri.
Adam B VetetoDepartment of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri.
John L JonesDepartment of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri.
Chen GaoDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Christoph RauDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Chad M WarrenDepartment of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois.
Paula J KluthoDalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri.
Linda AlexDalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri.
Stephanie C Ferreira-NicholsDalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri.
Jan R IveyDepartment of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri.
Pamela K ThorneDepartment of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri.
Kerry S McDonaldDepartment of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri.
Maike KrenzDepartment of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri.
Christopher P BainesDepartment of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri.
R John SolaroDepartment of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois.
Yibin WangDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
David A FordDepartment of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University- School of Medicine, St. Louis, Missouri.
Timothy L DomeierDepartment of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri.
Jaume PadillaDepartment of Nutrition and Exercise Physiology, University of Missouri-Columbia, Columbia, Missouri.
R Scott RectorDepartment of Nutrition and Exercise Physiology, University of Missouri-Columbia, Columbia, Missouri.
Craig A EmterDepartment of Biomedical Science, University of Missouri-Columbia, Columbia, Missouri.
Funding
Sarcomeric Modifications and Progressive Cardiac MaladaptationP01HL062426 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SOLARO, R JOHN · 2000 to 2020
$42.4MResource Core for National Swine Resource and Research Center (NSRRC) Years 21-25U42OD011140 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Kiho Lee · 2012 to 2026
$26.7MPORCINE MODELS OF CORONARY ARTERY DISEASE IN DIABETESR24RR013223 · NCRR · UNIVERSITY OF MISSOURI-COLUMBIA · PI STUREK, MICHAEL · 1998 to 2007
$4.5MEXERCISE, DIABETES, &CORONARY SMOOTH MUSCLE Ca2+R01HL062552 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI STUREK, MICHAEL · 1999 to 2013
$4.5MMolecular Identity of the Cardiac Mitochondrial PoreR01HL094404 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI BAINES, CHRISTOPHER P · 2009 to 2018
$3.6MCardiomyocyte TRPV4 and cardiac dysfunction following ischemia-reperfusion in the aged heart.R01HL136292 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Timothy Lee Domeier · 2017 to 2026
$3.5MEpigenomic Mechanisms of Heart FailureR01HL129639 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VONDRISKA, THOMAS M. · 2015 to 2018
$2.6MA Systems Approach to Dissect Genetic Basis of Heart FailureR01HL123295 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, WANG, YIBIN · 2014 to 2017
$2.6MCoronary Dysfunction, BK Channels, & Exercise in Heart FailureR01HL112998 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI EMTER, CRAIG ALLEN · 2014 to 2018
$1.8MBCAA Catabolic Defect in HF: Novel Mechanism and Therapeutic TargetR01HL140116 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, ZHAOPING · 2018 to 2021
$1.6MNovel Regulatory Circuit in Cardiac Hypertrophy Via RNA SplicingR01HL122737 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2014 to 2017
$1.5MSHP2 controls cardiac stress adaptationR01HL116525 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI KRENZ, MAIKE · 2013 to 2016
$1.4MBLRD VA I01 BX003271NCRR NIH HHS R24 RR013223NHLBI NIH HHS K01 HL125503NHLBI NIH HHS P01 HL062426NHLBI NIH HHS R01 HL062552NHLBI NIH HHS R01 HL094404NHLBI NIH HHS R01 HL112998NHLBI NIH HHS R01 HL116525NHLBI NIH HHS R01 HL122737NHLBI NIH HHS R01 HL123295NHLBI NIH HHS R01 HL129639NHLBI NIH HHS R01 HL136292NHLBI NIH HHS R01 HL140116NIA NIH HHS K01 AG041208NIGMS NIH HHS R01 GM115552NIH HHS U42 OD011140
Abstract
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet-fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to extending the understanding of how pre-existing cardio-metabolic syndrome can contribute to developing HF.
Indexed as
AB, aortic-bandedcardio-metabolic diseaseCON, controlEDPVR, end-diastolic pressure−volume relationshipEF, ejection fractionheart failureHF, heart failureHFpEF, heart failure with preserved ejection fractionHFrEF, heart failure with reduced ejection fractionIL1RL1, interleukin 1 receptor-like 1integrative pathophysiologyLV, left ventricleNF, nuclear factorpreclinical model of cardiovascular diseasePTX3, pentraxin-3WD, Western Diet
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.