Evidence map›Paper›PMID 31313950›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Loss of primary cilia increases polycystin-2 and TRPV4 and the appearance of a nonselective cation channel in the mouse cortical collecting duct.

Takamitsu Saigusa, Qiang Yue, Marlene A Bunni, P Darwin Bell, Douglas C Eaton

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Epithelial NaComprehensive Physiology · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. TRPV4: A Physio and Pathophysiologically Significant Ion Channel.International journal of molecular sciences · 2020
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Takamitsu SaigusaDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Qiang YueDivision of Nephrology, Department of Medicine, Emory University, Atlanta, Georgia.
Marlene A BunniDivision of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
P Darwin BellDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Douglas C EatonDivision of Nephrology, Department of Medicine, Emory University, Atlanta, Georgia.
Emory University · USUniversity of Alabama at Birmingham · USMedical University of South Carolina · US

Funding

UAB Recessive PKD Research and Translational Core CenterP30DK074038 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 2005 to 2019
$16.6M
Regulation of Sodium Transport in Tight EpitheliaR01DK110409 · NIDDK · EMORY UNIVERSITY · PI EATON, DOUGLAS C. · 2018 to 2021
$1.4M
Renal Mechanism for Hypertension in Polycistic Kidney DiseaseK08DK106465 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAIGUSA, TAKAMITSU · 2015 to 2019
$816k
The Role of Kidney Immune Cells in Acceleration of Cyst GrowthR03DK119717 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAIGUSA, TAKAMITSU · 2019 to 2020
$223k
NIDDK NIH HHS K08 DK106465NIDDK NIH HHS P30 DK074038NIDDK NIH HHS R01 DK110409NIDDK NIH HHS R03 DK119717
6 · The paper itself

Abstract

Flow-related bending of cilia results in Ca

Indexed as

AnimalsCalcium SignalingCiliaDisease Models, AnimalFemaleKidney Tubules, CollectingMaleMembrane PotentialsMice, KnockoutPolycystic Kidney DiseasesTime FactorsTRPP Cation ChannelsTRPV Cation ChannelsTumor Suppressor ProteinsUp-RegulationTg737Rpw protein, mouseTRPP Cation ChannelsTrpv4 protein, mouseTRPV Cation ChannelsTumor Suppressor Proteinscalcium channelciliopathymechanosensorpolycystic kidney diseasetransient receptor potential

Identifiers

PMID31313950
PMCPMC6766628
OpenAlexW2961435442

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.